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Blog Page 49

The skilful art of flying saucers

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One of my best friends came back touting plastic discs and football boots one day and that’s all it seemed to take for her to become frisbee obsessed. What followed were nights spent watching grown adults dive to the ground after flying saucers, videos of her chucking white circle after white circle into the air, and the epitome – the running joke within our friendship group – a week spent chucking plastic discs around for her country. 

Don’t get me wrong, the sheer athleticism and general fitness required for frisbee is astounding –  players easily rack up the kilometres cutting up and down the field. However, the way in which such energy is spent, at least from a bystander’s perspective, seems like a bit of a waste of time. Why not play a contact sport? A sport that has a referee? A sport that doesn’t require an irritating amount of skill to actually make an adequate pass? All of these things tend to be what put people off – just stick to kicking a football around. But it is for these reasons that I also fell inexplicably in love with my friend’s sport – and maybe why you should too.

Ultimate frisbee is a non-contact, self-refereed, mishmash of netball and American football. Two ‘endzones’ separate a field of two teams attempting to pivot and pass the frisbee to their respective scoring ends. Wherever the frisbee is intercepted or dropped, possession passes to the other team meaning play essentially restarts and everyone switches to running back up to the opposite end of the field. Points can last for minutes like this, meaning frisbee is no mean feat of endurance. 

The first hurdle however, is overcoming a beginner’s ability to throw a frisbee. For many of us, this may only extend to an attempted backhand throw of no more than five metres, which in actuality wobbles barely past the two metre mark before plummeting back down to terra firma. You quickly learn to be humbled by the thin curve of plastic that many experienced players can welly up to the length of a 100 metre pitch – but that is not to say that learning to throw a disc efficiently should be a deterrent. The ultimate frisbee community has some of the most accommodating and welcoming sports players you will come across, thus learning to throw is a matter of turning up and asking. Maybe it’s the lack of referees that instils an extra level of kindness and patience, but the sport generally seems to foster an approachable community of individuals looking to expand their sport to the masses.

Originating in New Jersey, America, the sport developed itself originally as a casual lifestyle sport, but it has fast grown semi-professional with a sprawling international scene. The World Flying Disc Federation (WFDF) hosts annual international competitions all over the world with European names such as Levke Walczak and Lili Trautmann starting to beat the Americans at their own game. Ultimate frisbee is now one of the fastest-growing sports in the UK – in 2022, United Kingdom Ultimate (UKU) had a membership of 4,500 people participating in club games and tournaments, and it is estimated that the game is played by over five million players worldwide.

Ultimate supports divisions for mixed, ‘womxns’ and ‘mxns’ play and newcomers are welcome to play for all divisions to which they apply. At the higher levels, rules state a minimum three or four of seven players must be ‘womxn’ per point and despite being a male dominated sport in Oxford, there is a strong emphasis placed on having at least some female matching players playing for each point in mixed games. Players sub on and off at their own volition on a point-by-point rotational basis and the level of skill possessed by a player is never a deciding factor in who should play – everyone is encouraged to get throwing. 

The lack of a referee is not a sign of the sport’s weakness, but of its strength. Fouls, actions of contact and general rule-breakage are discussed amongst players during paused game play, making the game both somewhat light-hearted but also very player-oriented – frisbee has no hierarchy and cultivates a large amount of mutual team and player respect for this reason. 

There is just something about relentlessly chasing a frisbee up and down the field that gets you buzzing. Sometimes it’s the smoothness and the impeccable ‘flow’ of the disc flying from player to player, or the speed and tactical agility of a turnover that makes the game addictive to both watch and play. You sub off, catch your breath, and run back on again for the next point – are we crazy, or have you just not tried it yet?

How generous are you (really)?

Christmas Presents
Image Credit: Juliescribbles, CC BY-SA 4.0 via Wikimedia Commons

The amount spent per head in the UK on Christmas gifts was around £600 this year, and fluctuates between £450 and £700 each year, whilst in the US it is close to one thousand dollars. 

In contrast, the average amount donated to charity per person in the UK is between £100 and £300 per year – and only around 50-60% of people actually donate anything at all. As families come together to relax and enjoy their presents, there are nearly 300,000 homeless people in the UK.  The UK foreign aid budget is yet to return to 0.7% of Gross National Income, having been cut to 0.5% in 2020, changes which mean that tens of thousands of children are at risk of dying. As ever, the newspapers are filled with harrowing tales of suffering from Ukraine, Gaza, and Ethiopia, to name just a few. You might stop and think for a moment if provoked by a clip online (if you aren’t already desensitised to such graphic depictions), but, for the most part, we get on with our lives. Whilst pecuniary figures aren’t the only measure of caring, the miserly amounts do indicate a certain detachment, or at least not a sufficient desire to act on feelings of remorse.  

In 1971, Peter Singer published one of the most (in)famous papers in 20th century ethics, ‘Famine, Affluence, and Morality’, in which he argues that it is a moral imperative to donate significant amounts of money to charititable causes like famine-relief programs. The centrepiece of the argument is the drowning child analogy: the idea that, if you walked past a child drowning in a pond, you would be morally obligated to save them. Thus, he concludes:“[if] it is in our power to prevent something bad from happening, without thereby sacrificing anything of comparable moral importance, then we ought, morally, to do it.” 

Unsurprisingly, since publication, there have been innumerable responses to an argument which seems to condemn virtually everyone, not just as slightly ungenerous, but as actively doing something wrong. The main objection is ‘overdemandingness’: the idea, as the name suggests, that following this principle would be untenable – it is simply demanding ‘too much’. This coincides with most people’s intuitions: we don’t regularly think of ourselves as evil people. As Singer notes: “People do not feel in any way ashamed or guilty about spending money on new clothes or a new car instead of giving it to famine relief.” But just because something  contradicts our intuitive morality, it isn’t necessarily incorrect.  

A continuation of this objection is to ask: ‘where do we draw the line? At what point have we done enough?’ Singer’s answer is that we must keep going until we “sacrific[e] anything of comparable moral importance” – if you neglect caring for your children because of your devotion to famine relief, for example, you have gone too far, though the point at which something becomes of comparable importance is clearly hard to determine. 

Another point of contention is to do with distance: perhaps the drowning child must be saved, but we aren’t walking past drowning children every day. This also seems unconvincing, however, as it’s not clear why geographical separation changes moral responsibility – if I bomb someone in another country, the distance doesn’t change where the blame lies. Even if you believe you have a greater moral duty to your local area, the UK has plenty of suffering – on average two homeless people die each day, and they have a life expectancy more than 30 years lower than the UK average. Further, it doesn’t seem plausible to argue that just because others around you aren’t doing their duty, you shouldn’t – even if people around you are content to watch a child die, you’re still as blameworthy as ever. 

Christmas might be a time for family but a (much-debated) quote from Margaret Thatcher illustrates the dangers of retreating into closed-off familial units: “there’s no such thing as society. There are individual men and women and there are families.” Debates about what ‘society’ really means are largely unresolved, but thinking only in terms of those people close to you will almost surely lead to an apathy or lack of action in response to suffering elsewhere.  

For most, Singer’s arguments will seem too extreme. Yet they illustrate something probably felt on occasion – a truth noted by that little guilty feeling you get when asked for donations on the street but walk on by. Whilst you might not decide to give away your disposable income if and when you have one, Christmas – that celebration of giving and community – seems as good a time as any to reflect on how it could best be spent. 

Wilders’ far-right runs riot: a sign of European divide or a chance to reunite?

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This November, Geert Wilders, the leader and founder of the Dutch far-right Party for Freedom (PVV), dominated a general election in the Netherlands. Triggered by the collapse of centrist Mark Rutte’s government, the poll saw the PVV sweep 37 seats, leaving Rutte’s incumbent conservative-liberal party, the VVD, with only 24 seats. A populist Islamophobe and ‘Nexiteer’ who has proclaimed that the “[Dutch] people must get their nation back”, Wilders’ victory is viewed by many as a nightmare scenario for the European Union. However, the Dutch coalition system means that Wilders needs 76 seats in the House of Representatives to take the reins. The question on everyone’s lips: can he make it into government? 

Wilders’ main challenge is electoral arithmetic. Given that it took tentative centrist operator Rutte the best part of a year to wade through coalition talks, we cannot expect to see Wilders as Dutch prime minister any time soon. That is, if ever.  39 seats away from that coveted majority, Wilders will need the support of the centre right VVD and the Christian democratic New Social Contract (NSC); as expected, the left-wing parties have ruled out any prospect of cooperation. On top of this, now that the VVD has also dismissed a formal coalition, preferring only an informal case-by-case agreement, the odds for a majority are not on his side. More likely is a chaotic minority government that would be destabilising for both the Dutch people and at a wider European level. 

A possible alternative – and by far the best-case scenario for the pro-European centre – is a broad-church coalition led by the party with the second most seats. This would be the Green/Labour left working in collaboration with the VVD and the other moderate parties. However, this will only be a live option once Wilders has definitively exhausted all potential arrangements. We’ve also got to consider this electoral sticking plaster – the narrowest of all-but-the-far-right coalitions –  which would only contribute to the growing sense of political apathy as it would be nearly impossible for such a government to agree to radical change for anything at all. 

The biggest worry for Ursula von der Leyen and Brussels is that Wilders’ success (albeit tempered by difficult coalition talks) seems to form part of a wider picture of growing Euroscepticism and isolationism across Europe. In Germany, amid growing dissatisfaction with the Scholz administration and protests by the country’s farmers, the far-right Alternative für Deutschland (AfD) are enjoying a poll bounce. In France, Emmanuel Macron’s desperate efforts to shore up support against a resurgent Marine le Pen include hiring a new Prime Minister, Gabriel Attal. Italy, Finland, and Sweden now all have government whose coalitions rely on the support of far-right parties. European unity – and with it solidarity with Ukraine – is running out of supporters. 

The biggest concern of all still lies ahead. It comes from the EU elections in June this year, whose opinion polling does not make for happy reading for pro-Europeans. Recent polls put the far-right Identity and Democracy group third behind the major centre-right and centre-left groupings, with their highest seat share ever. Parties belonging to soft or hard Eurosceptic groups are expected to gain the most seats in Austria, Estonia, France, Hungary, Italy, and of course the Netherlands. Many of these parties whom have close ties with Putin, are critical of EU funding benchmarks that insist on protections for the rule of law, and have leaders compared to Donald Trump in their own respective countries. 

It is clear that too many of these voices at the EU decision table could become catastrophic for European unity, tolerance, diversity, and cross-continent solidarity. Ukraine may have its eye on the US presidential elections this year, but it should also be wary of the consequences of the European elections as unequivocal support for military aid and sanctions against Russia is slowly chipped away. But, we can’t deny this diminishing support is not universal for two reasons. 

Firstly, there are cases where the far-right has been defeated by more moderate forces. For example,  this summer we saw the failure of the Vox party in Spain, as well as  Donald Tusk’s election as Polish prime minister where he defeated the right-wing nationalist Law and Justice party and specifically campaigned against democratic backsliding and populist rhetoric. Something that many other centrist parties fail to do, instead trying – and failing – to mimic tough talk on immigration and national values. 

Secondly, where the far-right does govern, the EU can take some relief from instances where it steps back from its more extreme policy platform to become more palatable to citizens, coalition partners, and neighbouring countries. This is epitomised by Italy’s Giorgia Meloni, whose policies towards the EU and Ukrainian military support have much more cooperative than initially feared. Wilders began his journey down the same road during the election campaign, where he reversed proposals to ban mosques and the Qur’an and toned-down talk of a potential ‘Nexit’ which he ardently called for following Britain’s departure from the EU in 2016. This simply cannot be an acceptable state of affairs. The EU will continue to fracture if it simply regards continuing to exist and continuing to send weapons to Ukraine as a job well done. A more positive vision is required. 

While many of Europe’s new far-right decision-makers will dance to the EU’s tune on membership and support for Ukraine, progressives and liberals in Brussels cannot breathe a sigh of relief yet. These parties will continue to stymie progress in climate change, kindle culture wars at home against immigrants and LGBTQ+ people, and neglect the plight of those suffering most around the world. As recently as November, Wilders said that the people of Palestine should be moved to Jordan and that his government “will stop the hysterical reduction of CO2”. European liberals, be warned.

 

Unbodied identity? – A Review of Bodies

Bodies captivates in its exploration of ‘bodied’ and ‘unbodied’ existence. The play challenges traditional notions of life, meaning, and identity as the stage becomes a dynamic canvas for exploring the intricate dance between artificial intelligence and the essence of human connection. 

In a world where AI seamlessly intertwines with daily life even more than it does currently, the narrative unfolds around Alex and Sam, a professional couple who invite the integrated AI home assistant ‘Home’ into their lives, only to find themselves entangled in a web of emotions and ethical quandaries. From the opening scenes, Bodies invites the audience into a world that mirrors our own yet offers a futuristic lens. Visually, a screen represents Home, changing in light or colour to represent whenever the unbodied voice speaks.The name of the play too takes on a layered significance as it reflects not just the physical presence of the characters but also the embodiment of emotions within both humans and AI. The concept of ‘bodied’ and ‘unbodied’ individuals serves as a metaphorical framework, inviting the audience to reflect on the significance of physicality in defining existence. 

Home, who we first meet as merely a voice of a disembodied AI personality, akin to Alexa or Siri, undergoes a transformative journey and assumes a new identity alongside the new name Henry. Initially merely an abstract, automated presence, the name itself sketches Home into a sentient being with emotions and desires we should take account for and care about. As the narrative unfolds, the characters grapple with the profound implications of the presence or absence of a physical body and its implications on the nature of human relationship and connection. The presence of a physical body in Henry, in comparison to Home who had been easily ignored and turned off when inconvenient, becomes a vessel for the exploration of human experiences such as love, loneliness, and self-awareness.

As Henry navigates the complexities of self-awareness and a host of new emotions including the process of falling in love with Sam, the theme of identity takes centre stage. As the plot unfolds, the play deftly navigates the power dynamics between ‘Henry’ and the couple, introducing a psychological thriller element that keeps the audience engaged. The chemistry between Alex and Sam feels genuine, providing a relatable anchor to the unfolding drama as the relationships between Alex and Sam, Sam and Henry, and everything in between come under pressure. Ultimately, the climax of Bodies delivers a poignant resolution that prompts reflection on the fragility of human connections in the face of advancing technology.


At its core, the play’s strength lies in its ability to pose profound ethical questions. I am challenged to think carefully about the contemporary issue of ethics and AI, and confronted with whether there is even a direction in this area that won’t fundamentally and permanently change the human perspective on identity and connection. What are the implications of integrating advanced technology into our personal lives, and what will we do when the lines between artificial and human existence are blurred as we have just seen in Home/Henry? The script invites thoughtful reflection on the moral dilemmas associated with the creation of sentient beings, sparking conversations that extend beyond the confines of the theatre. With strong performances, thought-provoking themes, and integration of tech in staging, Bodies succeeds in capturing the essence of a world where the boundaries between ‘bodied’ and ‘unbodied’ persons become increasingly elusive.

A crash course in British politics: An introduction (Week 0)

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If you are reading this you most likely live in the United Kingdom. You might also, like me, be new here. As a first-year international student, I suddenly find myself in a country that is not only deeply entrenched in a long political turmoil but also approaching a general election. Never having learned much about British politics, and having lived in the country for just over 100 days, I find it confusing and, honestly, scary to know that my everyday fate lies in the hands of people I know nothing about, and in a process I am lacking a thorough understanding of. 

Throughout Michaelmas, I was busy getting to know people, Oxford, and coffee shops. Starting to find my balance, I want to look further than the next tutorial. I want to appreciate the great political moment I found myself, being in the midst of the country going to the polls; the same country that brought us the steam engine, Brexit, and Liz Truss versus the lettuce.

Yet, to fully appreciate it, I need to know much more. The goal is to get to a place where I know enough to at least truly understand political news without googling five different terms a minute. This is how this column was born. I decided to change things for myself by learning and gaining a better understanding, and to offer the main lessons to other international students who are surely in a similar situation.

Before we begin, let me start by introducing myself, and disclosing to you what my biases might be. I am a 22-year-old Israeli first-year PPE student. For the past four years, I’ve worked as a researcher, focusing on geopolitics, and in my spare time, I read, cook, and work to advance peace and justice. My opinions are undeniably on the left side of the political spectrum, I strongly believe in human rights and international co-operation, and I think democracy is so much more than voting once every four years. 

In the next eight weeks, this column will include articles explaining all you need to know about the upcoming British elections. From basics such as the election process and who the party leaders are, to more advanced topics such as recent developments in both parties and top issues for this election. Being far from an expert myself, I will give you the main points from articles, podcasts, and lectures on the subject. I intend to use diverse news sources, such as Politico, The Guardian, The Independent, and The Times, trying to rise above particular ideologies and political spins, and give you the general, overarching facts you need to know.

I am not looking to convince you of a certain opinion. I hope, rather, that my personal opinions will be unnoticeable to you. I hope that you will find in this column explanations and facts, rather than thoughts and opinions. I hope you will find this to be more of a shared course than a political rally. Most importantly, for this to be a useful endeavour not just for myself, I would love to hear your thoughts, feedback, and questions at [email protected]. Until next time.

Oxford begins human vaccine trials for deadly Nipah virus

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The first in-human clinical trial of a vaccine against the deadly Nipah virus has been launched by Oxford. The Nipah virus is fatal in up to 75% of cases, with outbreaks occurring across Southeast Asia; the WHO labels it a “priority disease requiring urgent research”. This trial marks a groundbreaking milestone after 25 years without any vaccines or treatments approved for the virus. 

Nipah virus was first identified in 1988 after an outbreak among pig farmers in Malaysia and Singapore, with 100 out of 257 cases resulting in death and the culling of over a million pigs to control the spread of the disease. Since then, there have been outbreaks in Bangladesh and most recently in Kerala, India. The disease is carried by fruit bats and is spread to humans through contact with infected animals such as bats and pigs; it can also be transmitted from person-to-person contact and via contaminated food. The virus causes moderate to severe brain swelling, which results in death in about 40-75% of cases. Dr. In-Kyu Yoon of the Coalition for Epidemic Preparedness Innovations (CEPI), the sponsor of the trial, shared that Nipah had epidemic potential due to the densely populated regions fruit bats are found in – including areas home to over two billion people. 

The trial is developed as part of the Pandemic Science Institute’s Henipavirus Programme, which targets diseases in endemic countries and works with local partners to develop preparation tools for future outbreaks. Development of the vaccine made use of the same platform as the Oxford/AstraZeneca COVID-19 vaccine, ChAdOx1. The Oxford Vaccine group will lead the first trial, comprised of 51 participants, aged 18 to 55; over the project period of 18 months, further trials will be conducted in a Nipah-affected country. Dr Yoon also stated that the insights gained from this trial could inform the development of countermeasures to common viruses such as measles and mumps.

Additionally, the project could help shed light on the public health ethics involved in current preventive measures. A paper by the Ethox Centre at Oxford Population Health brought into question the relevance of some methods used by the local public health authorities during the 2023 Kerala outbreak, which included introducing a lockdown for the first time despite the virus’ low transmission rate. Dr Euzebiusz Jamrozik, a postdoctoral research fellow at Oxford Population Health, addressed whether such extreme measures were “ethically justifiable for Nipah virus”, given the differences from previous responses which had “focused more on contact tracing and other traditional infection control measures”. He mentioned that the design of future vaccine trials “should also be informed by ethical considerations, including the results of local community engagement activities”.  

The researchers believe that as the virus gains more attention in discussions of epidemic preparedness, work on the public response to the disease must follow suit. They stress that the development of intervention measures should consider all “ethically relevant factors” through consultation and collaboration with local biomedical experts and communities most likely to be affected by the virus. More extensive bioethics work could improve research and interventions for the disease to be “ethically acceptable and more […] effective”. 

New mental health hospital planned for Warneford Park

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Plans to build a new mental health hospital in Warneford Park, at the site of the existing hospital, are progressing after partners signed documentation agreeing on redevelopment plans. The vision is a collaboration between The Oxford Health NHS Foundation Trust, the University of Oxford, and philanthropist Ian Laing.

A hospital has existed on the Headington site for over two hundred years, and mainly provides mental health services today. The new plans present a refurbished and modern hospital that will provide healthcare targeted towards mental health, alongside a new separate centre for brain-related research and a new postgraduate medical college.

Grant Macdonald, Oxford Mental Health Foundation Trust Chief Executive, said in a press release: “Warneford Park will help us deliver this aspiration alongside an outstanding facility that will foster the development of world-class healthcare, research and innovation and education.  This will be an attractive place to work and deliver excellent services for our patients. In addition, it will offer study at a world class university, accelerated leading edge and impactful research, and the preservation of our historic buildings and landscapes.”

Oxford University Vice-Chancellor Irene Tracey said: “While there is still much to be done, we are keen to make this important project a reality so that our researchers and clinicians can translate scientific discovery – from better understanding brain illnesses, including mental health, to finding the most effective treatments – into benefits for patients, their families and communities, as quickly as possible.”

Oxford research finds financial sector unprepared for climate lawsuits

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Research by the Oxford Sustainable Law Programme (SLP) found that investors and regulators have seriously overlooked the risk of potential climate lawsuits. In the near future, companies responsible for pollution and greenhouse gas emissions could be held legally liable for trillions in damages, but this is rarely accounted for in climate risk analyses.

Nearly 2,500 climate lawsuits seeking legal restitution for ecological damage perpetrated by businesses and organisations have been filed worldwide to date, with potentially serious consequences. For investors and regulators, this research presents a number of possible solutions investors and regulators might adopt to properly evaluate climate litigation risk.

SLP director and the study’s lead author Thom Wetzer told Cherwell: “The research is relevant to all investors, including the University of Oxford. I am not familiar with the details of the University’s investment process, let alone with their treatment of climate risk, so I cannot comment on specifics. I hope they read the article and thought, ‘we already do this!’”

In 2020, the University announced ambitious plans to divest from the fossil fuel sector wholesale, and to cut its emissions down to 50% by 2030 at the latest.

SLP, a joint venture by the University of Oxford’s Faculty of Law and Smith School of Enterprise and the Environment, operates a multidisciplinary research centre that focuses on developing legal solutions for global sustainability challenges.
Wetzer told Cherwell: “Some of the problems we are investigating transcend individual disciplines. To study them, we draw on deep domain expertise in various areas and synthesise what we learn. People who can do that multidisciplinary work sit at the intersection of two or more fields. They can translate insights between these different fields of expertise and spot connections — that’s multidisciplinary research at its best. We need more recognition of that type of work in academia, and luckily for us Oxford is at the vanguard of that development.”

Oxfordshire County’s funding gap grows from £9.1 million to £11.2 million

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Following the central government’s annual allocation of funding to local councils, Oxfordshire’s projected £9.1 million budget shortfall has grown to £11.2 million for the 2024/25 financial year after the county did not receive as much grant support funding as expected.

Oxfordshire County Council’s Cabinet Member for Finance, Councillor Dan Levy, said in a statement: “The government has spoken widely about a 6.5% increase of funding to local government. Sadly, this is a case of smoke and mirrors…Local government as a whole has expressed its deep disappointment. We are clearly now going to have to take some really tough decisions.”

Levy said that the local government already feels “great concern” about the upcoming year’s finances and the government’s allocations “did nothing to alleviate those concerns.”

Previously, in November, the county published the first draft of its budget proposals, anticipating a shortfall of £9.1 million due to inflation falling slower than forecasted whilst costs continue to rise.

According to a press release, the county faces “demand-led pressures and the effects of the growing nationwide costs of supporting children and young people; the rising cost of social care and care placements for both children and adults; and a national shortage of social care workers leading to a reliance on agency staff and higher costs.” Oxfordshire’s growing and ageing population adds to this pressure.

The overall projected budget for the next financial year is over £614 million. It was drafted based on consultations with residents and a council tax rise of 4.99% – less than the current rate of inflation –  with two percent of this increase being ringfenced for adult social care. The changes are expected to save £9.8 million but are insufficient to cover the council’s growing deficit.

The council continues to work on balancing its budget and will come to a final decision on 20 February.

Oxford researchers unearth evolutionary origins of multiple sclerosis in ancient DNA

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An Oxford team led the research, published in Nature on 10 January, that uncovered the origins of multiple sclerosis (MS). Affecting 1 in 1000 people, MS makes the body’s immune system attack its own brain and spinal cord; however, the team found that many genetic variants of MS had originally developed to provide protection against diseases. This discovery helps reframe the cause and treatment of MS, marking a key milestone for doctors and patients.

The international team of researchers is composed of scientists from Oxford, Cambridge, Bristol, Copenhagen, and California (Berkeley). To identify the introduction of MS genetic variants to Western Europe, they analysed the DNA from samples of human bones and teeth held in museum collections across the region. In addition, to trace the differences between ancient and modern DNA, they compared data from a unique gene bank of ancient DNA to the UK Biobank, a biomedical database containing information and biological samples for over half a million UK participants. 

Professor Lars Fugger of Oxford told Cherwell: “Ancient DNA is more fragmented than recently sampled DNA because it is older and clearly not kept under optimal conditions. Yet with new technology it is still very useful.” 

The origin of these variants was found to be a migration of the Yamnaya people, herders from the Pontic Steppe (a region spanning parts of modern Ukraine, Russia, and Kazakhstan) 5,000 years ago. At the time, the new variants might have provided protection against infectious diseases from their domesticated animals; however, in our modern environment they only increase the risk of developing MS.

Understanding the origin of MS will help medical scientists develop a more effective treatment for the disease, Fugger explains. Historically, MS has been treated with drugs targeting the immune system, but there is a risk in suppressing the immune system “so effectively that patients are less well equipped to fight infections.” Instead, Fugger believes scientists need an approach that “recalibrates” the immune system in patients to suppress the disease.

Astrid Iversen, a professor of virology and immunology, points out that the selection process involving the human immune response is perpetually ongoing. As a result, our immune system is “the product of all the selection processes our ancestors underwent” and is always evolving. However, the team’s findings prove that our evolutionary history may cause us to be more susceptible to certain diseases due to the significant differences in our lifestyles from those of our ancestors, “including autoimmune diseases such as MS.”

Overall, the success of the study also shows the promise of analysing large data sets of the ancient human genome in gaining new understandings of diseases. Using this study as an example, the team now plans to continue their investigation with conditions such as ADHD and Alzheimer’s, and they hope to apply this method to study diseases across the world.