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Oxford vaccine induces immune response in elderly people

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Analysis of the results from Phase II trials of the Oxford University COVID-19 vaccine has shown that it induces an immune response in older adults as well as younger volunteers, AstraZeneca has confirmed.

The development raises hope that elderly people, who are one of the groups at the highest risk of developing serious complication from COVID-19, could be able to return to a degree of pre-pandemic normality after receiving the vaccine.

The data, which is currently being peer-reviewed and will hopefully be published in a clinical journal, shows that volunteers over the age of 55 produced the same immune response to the vaccine as younger volunteers. The vaccine also caused a similar immune response in some participants over the age of 70.

The capacity of a vaccine to induce an immune response in a patient is known as its immunogenicity. As the body’s natural immune system gets weaker as a person gets older, some vaccines are less immunogenic in elderly patients and will not provide the same protection against a disease as it will for younger adults. The evidence that the Oxford vaccine is immunogenic in elderly volunteers is encouraging, because it indicates that one of the demographics who are most vulnerable to COVID-19 may be able to develop some protection.

The same data also showed that the vaccine had low reactogenicity in older adults, meaning that they developed few side-effects.

A spokesperson from AstraZeneca, the pharmaceutical company working with the Oxford Vaccine Group, told the Guardian: “It is encouraging to see immunogenicity responses were similar between older and younger adults and that reactogenicity was lower in older adults, where the COVID-19 disease severity is higher. The results further build for body of evidence for the safety and immunogenicity of AZD1222 [the vaccine].”

The global effort to develop an effective vaccine against COVID-19 currently includes 49 vaccines undergoing clinical trials on humans. The Oxford vaccine has been undergoing combined phase II/III trials involving 50,000 participants in Brazil, South Africa, India, the United Kingdom and the United States. AstraZeneca announced on November 1 that the vaccine would be undergoing “rolling review” in the United Kingdom, meaning that the Medicines and Healthcare Products Regulatory Agency would analyse data from the clinical trials in real time in order to speed up the approval process.

While AstraZeneca and Oxford University have been optimistic that the vaccine will be available for limited use within the coming months, some experts have cautioned that it may take longer and that people at lower immediate risk from COVID-19 may have to wait. Soumya Swaminathan, who has served as Chief Scientist at the World Health Organisation since 2016, has said that any vaccines which are available by 2021 would have “limited quantities” and that “most people agree, it’s [vaccination] starting with healthcare workers, and frontline workers…and then the elderly…a healthy young person might have to wait until 2022.”

The process of developing a vaccine can also be interrupted if any volunteers develop unwanted adverse reactions to the vaccine. Global trials of the Oxford vaccine were “voluntarily paused” on 6 September after a British volunteer developed transverse myelitis. Although the trials restarted in most countries soon afterwards, it took until the end of October for trials to resume in the United States. There were concerns that the vaccine may be delayed further after a Brazilian volunteer died in on 19 October, but an investigation found the volunteer had only received a placebo, and the death was unconnected to the vaccine.

Although the Oxford vaccine is expected to be one of the first to receive approval, Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine warned that “it is wise not to be too optimistic until those [later phase] trials have completed.”

Blenheim Palace to receive £600,000 restoration

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Blenheim Palace, Oxfordshire’s only UNESCO World Heritage site, is due to undergo a £600,000 restoration to its chapel.

The chapel, constructed in the early 18th century and designed by the architect Sir John Vanbrugh, has experienced water damage, a series of leaks harming the paint and plasterwork. The focal point of this chapel, which underwent further modifications in the Victorian era, is a monument designed by Sarah Churchill, 1st Duchess of Marlborough, depicting her late husband, famed military commander and statesman John Churchill. The monument portrays John as a Roman general along with his two sons, this tribute to the first family to reside in the Palace a striking example of English Baroque design.

Blenheim Palace’s website refers to “significant issues” with the chapel stemming from environmental causes. Speaking to the BBC, conservation manager Richard Bowden saw that the chapel’s ‘internal conditions’ were causing structural damage.

Concerns have been raised about the state of Britain’s historic buildings in recent weeks after the manor house which served as the set of BBC’s Poldark was found to be in disrepair. Coronavirus restrictions have placed an added burden on such sites, limiting their income from tourist visits.

Image credit: BjoernEisbaer / Wikimedia Commons

BREAKING: Alan Rusbridger steps down as LMH Principal

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Alan Rusbridger, Principal of Lady Margaret Hall (LMH) and former editor-in-chief of The Guardian, has confirmed that he will be leaving the college at the end of academic year. In an email to LMH students, he cited his involvement in “a variety of projects seeking to address the acute crisis of information and democracy which is afflicting so many societies” as the reason for his decision.

The Principal stated in his email that Lady Margaret Hall’s Governing Body had asked him to stay on for a full second term of five years. Rusbridger has declined the offer, committing instead to “devoting more of my time to the question of trust in media and society”.

Alan Rusbridger was elected Principal of Lady Margaret Hall in December 2014, one week after stepping down as editor-in-chief of The Guardian. During his time at LMH, he implemented the Foundation Year scheme, a one year, fully funded course that takes academically able students from underrepresented groups and through a combination of academic and personal support enables them to fulfill their academic potential. The vast majority of Foundation Year students have been successful in earning a place at Oxford or other Russell Group universities after completing the scheme. Since the first cohort of Foundation Year students joined LMH in 2016, both Oxford and Cambridge have committed to implementing the scheme on a university-wide basis.

Rusbridger highlighted his work to improve access to LMH and the wider University in his email: “Our work on inclusion inspired the largest promised donation to the College in living memory. Applications to the College have soared as the profile of LMH has risen. We have opened the community up to numerous conversations with leading public figures. There’s so much to look back on with great satisfaction.”

In addition to his duties as Principal, Alan Rusbridger has published several books on the media, democracy and wider issues in society. His most recent publication, “News and How to Use It: What to Believe in a Fake News World” (2020), will be released on November 26th. As Principal of LMH, he held a number of “In Conversation” events with prominent figures who gave talks and answered questions of LMH students. Some of them included Lady Hale, Sir Jeremy Farrar and Edward Snowden.

Alan Rusbridger was appointed chair of the University’s Reuters Institute for the Study of Journalism in 2016. In 2020, Rusbridger was announced as one of the first members of the Oversight Board created by Facebook. Regarding his work in the future, he said: “I have found myself recently in some demand to become involved in a variety of projects seeking to address the acute crisis of information and democracy which is afflicting so many societies. I am keen to do what I can to help address this crucial issue.”

Regarding the search for a successor, Rusbridger stated in his email: “The College has embarked on the search for my successor and I will, of course, do my very best to support them and ensure the smoothest of transitions.”

The college said that Rusbridger has “helped transform LMH into an outward-facing College widely known for its inclusivity, diversity and accessibility”.

Alan Rusbridger said in a statement: “I have informed the Governing Body that I will be stepping down as Principal of LMH at the end of the academic year.  By then I will have had six extremely satisfying and productive years in Oxford and, while I was very pleased to be offered a second term of five years, I feel the time will be right to move on.

“I am very proud of the work we have done on inclusion – especially, but not only, the launching of our pioneering Foundation Year for students from under-represented backgrounds.  It is heartening to see this scheme now being rolled out across both Oxford and Cambridge Universities. Hundreds, if not thousands, of young people will have their lives changed over time.

“I have recently been asked to get involved in a variety of projects seeking to address the crisis of information and democracy which is afflicting so many societies.  I am keen to do what I can to help address this crucial issue. While I will regret leaving the very many friends we have made in Oxford I look forward to devoting more of my time to the question of trust in media and society.”

Christine Gerrard, LMH Vice Principal, said: “Alan Rusbridger has announced his intention to stand down as Principal of LMH at the end of September 2021. We owe him an enormous debt of gratitude. Alan’s visionary leadership has transformed LMH. He has launched numerous initiatives which have required both courage and energy, from the ground-breaking LMH Foundation Year scheme (now taken up by both Oxford and Cambridge universities), to the regular inclusion in college life of high-profile figures in the media, politics and arts as both Visiting Fellows and guest speakers. His work has captured the imagination of the wider world and put the college on the map. The phrase he adopted early on – ‘LMH: Changing Lives since 1879’ – captures Alan’s ability to harness LMH’s pioneering spirit to wider 21st century access and equality initiatives. Alan’s shaping presence will remain strong in years to come.”

Image credit: Internaz/ Flickr. License CC BY-NC-SA 2.0.

This article was updated at 16:35 on 6.11.20 to include comment from Alan Rusbridger and Christine Gerrard.

Long COVID: What can we do?

“Ease the restrictions, let the majority get back to their normal lives, but continue to shield the vulnerable.” It is common to hear such arguments hinting at the possibility of achieving herd immunity, and they usually invite heated debate. But what if we cannot determine exactly who the ‘healthy’ and ‘vulnerable’ people are?

According to data collected by the COVID Symptom Study since the start of the pandemic, 5% of people who contract COVID-19 are likely to suffer from the symptoms for more than 8 weeks. These persistent symptoms include fatigue, breathlessness, headache, insomnia, chest pains, and intermittent fevers. While ‘long COVID’ is more likely to affect older than younger people, 10% of 18- to 49-year-olds who contract the virus suffer from long-term complications.

What does all this mean for our approaches to managing the virus? Certainly, the government should pay greater attention to long COVID. In a crisis full of unknown variables, it pays to stay alert for new curveballs to avoid being caught off guard in the future. Since long COVID has, over the recent months, significantly impacted those who are of working age, the government needs to actively enforce measures meant to keep workplaces COVID-secure. Managing long COVID successfully can help to alleviate potential economic impacts too: by maintaining the health and productivity of workers, future economic recovery can proceed more smoothly.

But at this point, resources are already stretched thin – the beleaguered test-and-trace system, meant to be ‘world beating’, has struggled to keep up with the rate of spread. The government also needs to prevent hospital beds and ventilators from running out over the winter. Indeed, the second nationwide lockdown across England, which began on 5 November, is likely in response to new estimates that the death toll in winter could exceed the earlier predicted ‘worst-case scenario’ of 85,000. The focus of the government now is to protect the NHS, while also buying time to scale up the test-and-trace system to meet demand. With these pressing matters occupying much of the government’s attention, the issue of long COVID is unlikely to be high up in their list of priorities – despite calls from organizations like Long Covid SOS and the Long Covid Support Group to pay greater heed to the issue.

What can we do then, at the individual level? Certainly, the public should be cognizant of the effects of long COVID. There might initially have been low public awareness of long-term implications because it took time for such cases to be documented; however, there is now sufficient evidence of long COVID that it can no longer be ignored. Ideally, awareness of long-term complications that occur even in younger people should remind those who perceive themselves as invulnerable that the virus can be far more severe than the common cold.

However, such depressing stories in the media will also add to public distress, at a time when mental health is already taking a hit in response to the second lockdown. It may be more demoralizing than beneficial for long COVID to settle into the public consciousness. Nonetheless, in such a crisis, awareness should always be prioritized: it is far better that people recognize the severity of a crisis and take individual precautions, rather than ignore the full extent of risks and pay dearly down the road. Information shared should therefore always be factual, well-researched, and should not be spread with the intention of fearmongering. While there have been instances of individuals coming forward to share their experiences of long COVID on social media, official communication by the government and mainstream media should always be based on the research findings of credible scientific institutions, rather than sensational, unverified anecdotes.

Still, the greatest hurdle is perhaps the growing fatigue towards pandemic restrictions that will prevent scientific advice from being taken seriously. Behavioural economists have documented how hyperbolic discounting creates preferences for smaller rewards in the present, as opposed to larger rewards that can only be reaped in the future. Having been deprived of many opportunities for socialisation and recreation over the past few months, it will be difficult to convince individuals – particularly the young – to continue prioritising their health risks over their personal liberties.

It is clear that the COVID-19 pandemic will not ‘end’ in a straightforward manner anytime in the near future. Even when an effective vaccine has been found, it takes time for it to be produced and distributed at a sufficiently large scale. What we can expect instead is for restrictions to be periodically loosened and tightened in the coming year, in response to changing levels of spread. It will be a long winter, a long 2021, and a long nightmare for patients whose symptoms just won’t go away.

Original image: https://pixabay.com/fr/illustrations/maux-de-t%C3%AAte-migraine-m%C3%A9decine-3660963/

Covered Market to stay open during lockdown

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Oxford Covered Market has announced that it will remain open during lockdown. In line with government guidance, food traders within the market will be allowed to operate as before. Restaurants and cafes can offer takeaways but no table service. Other businesses within the market will sell goods online, which customers can pick up at the premises.

The full list of traders who will open as normal is: Bonners Fruit & Vegetables, Cardews of Oxford, David John Pies, Go Gym Stuff, iScream, M Feller & Daughter Butchers, Nash’s Bakery, Oxford Cheese Co, Pershore Seafood, Teardrop Bar, The Market Cellar Door, and Wicked Chocolate.

The following businesses are open for takeaways: A Taste of China, Alpha Bar, Ben’s Cookies, Brothers Cafe, Browns Cafe, Colombia Coffee Roasters, Donburi Inn, Moo-Moo’s, Sasi’s Thai, Sofi de France Cafe, Taylors, and The Oxford Sandwich Company.

Finally, these businesses will operate online for the duration of the lockdown: Blue Blood Sports, Fresh Clothing, Jemini Flowers, John Gowing Jewellers, Next to Nothing, Nothing, Oxford Skate Co., Oxford Soap Company, PinGui, The Cake Shop, The Collectors Company, The Garden of Oxford. A list of the Covered Market traders’ websites can be found here.

A comprehensive list of Oxford businesses that are operating online during the lockdown can also be found here.

Boris Johnson announced last Saturday that the whole of England would be placed under Tier 4 Restrictions from Thursday 5th November for four weeks until Wednesday 2nd December. Although schools and universities will remain open, all non-essential businesses have been ordered to close, although food takeaway and deliveries can continue.

Different households are not permitted to mix inside or in private gardens unless they are in your support bubble. You can meet one person outside your household for outdoor exercise, but people are encouraged to stay home except for essential activities. 

The rules for this lockdown are slightly different from the rules during the previous one. While businesses cannot serve customers, they can keep their premises open as a base for deliveries and click and collect.

The Covered Market is a frequent hotspot for tourists, who are attracted by its wide range of independent businesses located right in the city centre. It is now managed by Oxford City Council. The market was forced to close for the duration of the summer lockdown.  

Councillor Mary Clarkson, Cabinet Member for City Centre, Covered Market and Culture, said: “The months leading up to Christmas are vital for a lot of Covered Market traders, so the lockdown has come at a really bad time.

“But the traders are – as ever – simply amazing, and I think they’re all determined to make this work. To help them achieve that, we’ve decided to keep the Covered Market open. So if you’re looking to buy fresh food during lockdown or if you’re already starting to think about your Christmas presents, please support your market.”

Image credit: Jorge Royan / Wikimedia Commons

Oxford City Council launches anti-racist charter

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The Oxford City Council has launched an Anti-Racism Charter to contend with the “systemic racism” within the city.

The Charter defines Anti-Semitism, Islamophobia, and Anti-black racism, while making a commitment to work towards making Oxford an Anti-Racist city. 

Three commitments are given as initial actions to be taken: an annual review of the Charter, showcasing the talent and achievements of ethnic minorities and people of colour, and launching an Anti-Racist City Quality Mark that groups can adopt after signing and committing to the principles within the Charter.

Preceding the Charter, the Oxford City Council has been working to tackle racism more actively for over a year, having pledged to make Oxford an Anti-Racist city in August 2019. This has been further supported by the Council adopting definitions of both Islamophobia and Anti-Semitism and deciding to become a City of Sanctuary by making a commitment to supporting asylum seekers, refugees and migrants.

The Charter begins with the Council’s aim: “Our vision is: Collectively committed to being proactive, in making Oxford an anti-racist city.”

This is followed by statements promising to “have difficult and sometimes uncomfortable conversations about what it means in practice to be anti-racist”, to recognise institutional racism, and to understand that racism includes “unconscious, unintentional and indirect actions”.

The Council adds: “Without understanding the root causes of racism and how it affects people we cannot dismantle the institutional structures which give rise to it.”

The Council involved individuals from different groups and people of colour who have lived experience of racism. Seven focus groups have also been held, where issues like suitable terminology were discussed.

Launched digitally, the celebration included presentations from Councillors, an Oxford youth music performance, and recognition of those who have signed the Charter. In a press release, the Council stated that “representatives from schools, universities, businesses and communities will formally sign up to the charter at the event”.

A coalition of societies to fight racism has criticised the City Council for not dealing with racism in the city.

It said: “Currently as a result of pressure from below all our major institutions are announcing anti-racist charters and race equality action plans. The obvious danger here is that without sustained pressure from the grass-roots demanding greater accountability to local communities what we get left with is rhetorical ethics, tokenism and symbolic representation.”

Councillor Susan Brown, leader of the City Council, said: “Oxford’s Anti-Racism Charter is a step forward to tackle issues associated with structural and institutional racism. By understanding these issues, why they exist, we have the opportunity to ensure we are a city that works for everyone. It’s a challenge for us all to do things better, to be just and fairer, and a commitment from some of our biggest institutions to go further to tackle racism.”

Image credit: SJPrice/ Pixabay

Oxford faces calls to move all teaching online

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The University of Oxford will stay open despite the introduction of a national lockdown from Thursday.

As an educational institution, Oxford will continue to offer some in-person teaching. Planned in-person exams will go ahead in a COVID-secure setting and libraries will remain open.

The Oxford branch of the University and College Union (UCU) has written an open letter to the Vice-Chancellor demanding that all non-essential teaching moves online.

It calls on Oxford to follow SAGE advice which recommended universities transfer all teaching online unless face-to-face teaching is “absolutely essential”. Only teaching which involves practical or lab work should continue in person, Oxford UCU says.

It also calls for asymptomatic testing and for publicly available statistics on case numbers as they occur.

The letter, which has over 100 signatures, says: “Community members, the City Council, and businesses have worked hard to keep Oxford safe over the summer. It is now time for the University of Oxford to step up and play its part.

“We, as local residents, are concerned that the University’s activities will see a further escalation of cases, worsening the public health emergency and increasing the potential for local lockdowns.

“Oxford is one of the most unequal cities in the UK. The University has a responsibility to protect the community that lives alongside it. If the University is unable to demonstrate that it can ensure the safety of its staff, students, and the wider community, then it should cease all face-to-face activities.”

In an email to students, Pro-Vice-Chancellor Martin Williams confirmed that Oxford will not change its teaching policy in light of new restrictions. Final Honours Chemistry exams will still take place in the Examination Schools. However, Oxford University museums will close and restrictions on sport are expected.

Unlike the last lockdown, educational institutions can stay open and are exempt from some restrictions. The lockdown will last until 2nd December, three days before the official end of Michaelmas Term.

Some universities, such as King’s College London and Sheffield Hallam, have moved non-essential teaching online. The national UCU body has written to all Vice-Chancellors in England to request they adopt this measure.

The University reported 212 cases among students and staff for the week 24th-30th October. Across the city, Oxford has 135 cases per 100,000 people. This is below the average area in England, which has 153 cases, according to the BBC.

Aris Katzourakis, co-Vice-President of Oxford UCU, told Cherwell: “Oxford UCU has been pushing for the safest possible working conditions for its staff, the students, and the wider community. Over the summer, we have been trying to ensure these conditions, both for those that have been onsite throughout, but also for the beginning of term.

“As term approached, seeing the clear epidemiological situation, we have been arguing that as much teaching as possible should be done online, and that it was unnecessary to force students to return whether it was essential for them to do so or not.

“We are deeply disappointed by Monday’s announcement by the Vice-Chancellor that in person teaching is to continue despite the lockdown. We have written an open letter and urge all those who are concerned with the levels of in person teaching to sign it.”

A University statement said: “The University will continue to offer a mix of in-person and online teaching, in line with Government guidance for the new lockdown.  Planned in-person examinations will also continue to be administered in a COVID-secure setting, and libraries will remain open, as will our parks and gardens.  We will have to close our museums to the public, and there will likely be additional restrictions to sport – details of which will follow in the near future.

Oxford UCU has reaffirmed that the University should make COVID-19 related risk assessments available to staff unions. In August, the University said it is not “practical or useful to share all risk assessments with the Oxford UCU” and that it had met with unions frequently to discuss health and safety.

Image Credit to Theonlysilentbob/ Wikimedia Commons

Rapid COVID-19 test to be trialled on Oxford students

A rapid COVID-19 test that provides results within 30 minutes is being tested on student volunteers at Merton College and St. Hilda’s, as well as Durham University. 

The Feasibility and Acceptability of community COVID-19 rapid Testing Strategies (FACTS) study will assess the feasibility of the self-administered Lateral Flow Test in tracking COVID-19 in pre-symptomatic and asymptomatic individuals. This is part of the government’s “Operation Moonshot”, aiming for regular mass testing to reduce the spread of the virus. 

The Lateral Flow Immunoassay Test (LFIA) requires individuals to take a swab of their nose and throat and insert it into a tube of liquid for a short time, with a result provided after 20 to 30 minutes. They are aimed at potentially supplementing, rather than replacing, the standard use of RT-PCR (reference test polymerase chain reaction) tests.

Students will be asked to self-administer the LFIAs each week. Students have been provided with an explanatory video, will be offered an opportunity to ask researchers questions and are free to withdraw without giving any reason at any time. If they are unable or would not like to self-administer the test, students will be asked to attend a screening clinic “where the FACTS team will conduct the test and record the results”, explains the Participant Information Sheet.

As well as this, students will be asked to track their symptoms daily using the study’s app, and to conduct some five-minute online surveys on “the acceptability of the testing strategy”. The Participation Information Sheet explains that “a subset of participants [will also be asked] to take part in an interview to explore their experience and views of testing, what worked, and what could be done better.”

The pilot study is being organised by researchers at the University of Oxford’s Nuffield Department of Primary Care Health Sciences, in partnership with the Department of Health and Public Health England. It is receiving funding internally from the University. LFTs have been validated and undergone clinical testing. All participation in the study by students is voluntary. The study has been also been approved by the University Research Ethics Committee,

Professor Irene Tracy, Warden at Merton College, said in an email to students: “We believe this project will be an important contribution to national and international efforts to defeat the current pandemic and its wider consequences. The learnings will also be important in preparedness for future epidemics and pandemics.”

One student who had decided to take part explained why they got involved: “I wanted to do my bit, and I thought that it was incredible that I could be a part of something like this. It was a no-brainer, especially considering I’ve got vulnerable family members at home and I want to do what I can to make the world a little bit safer for them again.”

Students who receive a positive Lateral Flow Test result will be required to take the standard RT-PCR (reference test polymerase chain reaction) test via the NHS or Oxford University’s Early Alert Service, and self-isolate as necessary.

Oxford University have said that “it is hoped it [the LFIA test] will help identify those most at risk of spreading COVID-19 (those who are infectious, but not aware of this) and enable them to alter their behaviour accordingly, thereby breaking the chains of transmission and reducing the infection rate.”

The Pro-Vice Chancellor said that if the study proves effective, they aim to extend it across the whole University. 

What The Write Offs tells us about literacy in Britain

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Bake Off finishes, mum flicks through the TV guide a bit, turns back to Channel 4. “It’s Sandi’s new thing. There’s nothing else on.” We’re looking at a man in a smart shirt, black waistcoat, no tie, mid-thirties perhaps, being asked by Sandi Toksvig how to spell ‘clock’. He stumbles through the letters, strain obvious on his face, a questioning tone of voice making his struggle clear. “Well, you’ve inadvertently spelled ‘cock’, I don’t know if you’re okay with that.”

It’s looking like some kind of naff reality TV: ‘watch these fully grown adults fail at life!’ kind of thing. Clips of a team of eight trying to read a recipe aloud, follow written instructions, and spell words like ‘while’ and ‘child’ aloud – all unsuccessfully. These adults use fully conversant English when speaking, with average vocabularies and no difficulties in speech comprehension. I can’t quite work out why exactly these people, double, triple my age, are getting excited by writing the word ‘tube’ correctly.

By this point, I’m about to reach for my headphones and watch last week’s Gogglebox. The show seems a mixture of silly and frustrating and to be honest, I’m tired, I’ve been reading all day, and I don’t have the mental energy to watch other people try.

“Sorry mum, I just can’t watch this. Like… this can’t be real. How could you be an adult and not be able to read?” This was said more in a tone of dismay than genuine questioning, but she replies, “Well, I can believe it. Some people just never learnt. If you don’t really get it by the end of primary school, and no one helps in secondary school, then no one’s going to teach you.”

I can’t quite grasp the show’s angle, but Toksvig’s tone makes it clear that there are genuine, heartfelt intentions behind these scenes that feel unfamiliar to me. Dyslexia and other learning difficulties had been mentioned by this point, but the idea that reading and writing could still be inaccessible skills to adults had never really crossed my mind before. The remainder of The Write Offs showed me that it really should have crossed my mind, and it has been occupying it a lot since.

Paul, 43, is currently talking about his new-born. “I just don’t wanna [sic] be the guy who, when his kid comes home from school, at four or five, and goes ‘Daddy, what does this mean?’, doesn’t have the answer.” He’s shown trying to read a from a packet of nappies. “Er… it could be anything at all.” Sandi tells us he has the reading and writing age of a seven-year-old.

The eight ‘learners’ are now reading from a script together. It’s Paul’s turn, and he has visibly frozen up. This has happened many times so far in the program, and his response to Toksvig’s question of whether he is okay is not surprising either: “It’s kind of a bit scary.”

But the next few minutes shock me.

“I was an English and drama teacher. Three and a half years ago I had a stroke, damaged the left-hand side of my brain, and now I can’t read and write. It just changed everything really quickly, everything had gone in a second.”

The camera pans to him attempting to read a line of dialogue, squinting and stuttering on every word. He tries four times to say the word “effects”.

“My favourite stuff was Shakespeare. I have the complete Shakespeare at home, probably about three or four versions of it, in a box, in my garage.”

So do I. I’m an English student. I love Shakespeare. I could go now and pick up anything of his and read through it. Just like Paul could. Now he cannot even read the word ‘budget’.

Nothing has hit me as hard as this minute of TV for months. I had been sat in my little ivory tower of ‘well, why didn’t they just learn?’, but now I felt all that come down. Because I could see myself in Paul: exactly what happened to him could happen to me. I was hit by a basic lesson: you should not assume that everyone is starting from an equal point.

From here, I stayed a lot quieter, trying to properly digest the program and actually listen to the eight, rather than just my own preconceptions about what their difficulties in reading and writing must say about them. I feel like Craig is speaking directly to me when he says, “People who can read and write do take it for granted. […] Unless you’re in the situation you don’t know how hard it is.” Craig has dyslexia, along with at least 10% of the population.

Disruption to the everyday life of someone with dyslexia can range from slightly longer processing times when reading and writing, struggling to remember the words someone used, to thorough disruption of what most would consider their usual routine. But dyslexia does not affect IQ: people such as Einstein and de Vinci are now thought to have been on the dyslexic spectrum.

The number of British adults who struggle to read and write includes some who are dyslexic, and some like Paul who have suffered brain injuries. Many other factors may place people in the category of ‘functionally illiterate’, which the National Literacy Trust describes as those who can “understand short straightforward texts on familiar topics accurately and independently, and obtain information from everyday sources, but reading information from unfamiliar sources, or on unfamiliar topics, could cause problems.” Over 7 million people in the UK are functionally illiterate.

“I can believe it,” my mum replies after I sceptically read this stat out to her. She works in one of the local village primary schools. “Some of the kids who leave us, they can barely read and write. No one’s going to sit down and teach them how to write at secondary school if they don’t already know. I think we fail them.”

Most children start reading around the age of 4, but if they are not talked to, listened to, asked questions, and interacted with in other ways from the earliest stages of their cognitive development, it will be exponentially harder for them to catch up with the progression of their peers as they grow.

This is why affective access and outreach are important. Essential. We sit in the libraries of Oxford, reading ground-breaking theses, while in this very constituency 12.5% of residents hold no qualifications. We cannot strive for progression in our diverse fields without considering where progression is needed, closer to home: the UK has the largest literacy gap between employed and unemployed in the Western world.

Clearly, the decisions being made at the top are not filtering down to make an effective system. Perhaps this is partly because those decision-makers are ignorant of the reality. With a cabinet that was 64% privately educated (compared to 7% of the country as a whole), this is hardly surprising.

Government-backed research has found that schools with an ‘Outstanding’ Ofsted rating have better performing students than those from schools that ‘Require Improvement’. Selective and fee-paying schools have the best performing students. You don’t need me to tell you that most of the best performing children are thus from most affluent families. Of course, not all well-off people have high literacy rates, and many less-well-off people do. But the trend is still striking: Britain’s most influential people are over 5 times more likely to have been to a fee-paying school than the general populatio[EH1] n. While the results of this system are far from the only factors limiting the literacy levels of UK adults, they are a large part that needs urgent addressing. The Write Offs shows that effective help can most definitely be given: all eight of the participants progressed at least 3 school-years of reading and writing in 16 weeks.

34-year-old Dean, a telecoms engineer with the reading age of a nine-year-old, reminded us at the end of the program why this help is necessary.

 “Did you know that there is a staggering number of young offenders with reading and writing difficulties. Now, imagine if these young offenders were given a teacher like we’ve had. Someone to tell them that their big, beautiful brains just think differently to everybody else’s and need teaching in a different, more informed way. Albert Einstein, Sir Issac Newton, Thomas Edison, all had a dyslexic brain, just like mine. My question to you all is do you think we could stop wasting good minds? Do you think we could unlock the next Einstein?”


Wake up and smell the… nothing

Coronavirus affects the body in a plethora of different ways. It infects the upper respiratory tract leading to a cough and shortness of breath, it causes congestion that blocks sinus drainage passages and leads to headaches, it triggers the body’s production of cytokines leading to fever and inflammation and for many people, it messes around with their sense of smell and taste.

Our ability to detect smells and odours comes from a little, specialised piece of tissue in our nasal cavities known as the olfactory epithelium. This patch, whilst it appears small, actually contains around 50 million nerve cells covered in tiny hairs. These are called cilia and they have receptors that can bind the molecules that enter your nose and dissolve into the mucus that lines your nasal passages. This binding triggers an electrical signal that travels to the olfactory bulb, which is a sort of neuron relay station. They are then passed along the olfactory nerve, which carries the signal to your brain. Every odour we experience produces a unique firing pattern of neurons, allowing us to distinguish between similar smells.

A lot of cases of anosmia are caused by malfunctions in some part of this olfactory system. There are many known respiratory viruses that interfere with our ability to smell and it seems that coronavirus is able to do this not by attacking the olfactory nerve cells directly but the cells that support them.

The researchers at Harvard who discovered this are encouraged by their findings as it suggests the virus is unlikely to cause permanent damage. “I think it’s good news” said Sandeep Robert Datta, one of the co-authors of the Harvard paper, “because once the infection clears, olfactory neurons don’t appear to need to be replaced or rebuilt from scratch.” That means anosmia should be temporary, disappearing once the infection has been cleared.

But if coronavirus affects the olfactory neurons, why is that so many people find they can’t taste either? Well, only some of what we taste comes from our taste buds. There are hundreds of these taste buds found in each of the thousands of the little bumps, or papillae, on your tongue. These are able to detect the sensations of bitterness, sweetness, sourness, saltiness and umami. However, most of what we taste actually comes from the aroma of food. These odours travel down our nasal passages, where we detect them, rather than coming from your mouth. If you bite into a strawberry, your tongue will detect that it is sweet, but it is the aromas in your nose that tell you it’s strawberry flavoured.

It was about three days after my positive test result that I noticed I couldn’t taste or smell things as well as I normally could. I stopped being able to taste cups of tea (a realisation that any British person will find deeply upsetting) and I didn’t notice the burning toast that nearly set off our fire alarm. Soon I couldn’t taste or smell anything much at all. Ageusia, the scientific term for partial or complete loss of the ability to taste, is a pretty perplexing experience.

Once you lose your ability to taste, what do you eat? I had a lot of people in my house joking that it would be the perfect time to go on a health kick. “Eat nothing but kale,” one of them laughed, “you won’t be able to tell how bad it is.” That is one potential strategy, but it disregards the multifaceted role that food plays in our modern lives. Most of us are fortunate enough to be able to select what we eat largely based on what we feel like and what we will enjoy; food is not simply a fuel, but is instead a means of socialising, a response to emotions, a way to fill the time (and once you’re in isolation – you really aren’t short on time). And on top of that food is a multisensory experience. Especially if you can’t smell, as I couldn’t, the texture of the foods and the way they look becomes a whole lot more important. Just because you can’t taste it, that doesn’t mean you will be satisfied after eating a big bowl of kale.

So, what did I eat? Everyone who I have spoken to has had a slightly different experience of losing their taste and smell, but I personally found that the foods I wanted to eat were low on flavour and big on texture. This might sound counter-intuitive when your tasting capacity is reduced, but I found something comforting about eating foods that didn’t taste of much even when I could taste everything. I particularly liked foods with very distinctive textures; things like crisp iceberg lettuce, airy rice cakes, buttery toast, crunchy bowls of cereal and creamy avocado (I was very surprised to find out that even at my lowest tasting ability, I could also still taste avocado – I found my middle-class silver lining).

Now it has been a week since my other coronavirus symptoms stopped, but I still cannot taste or smell much at all. In spite of that, I am still hopeful. The research does seem to suggest that it will come back eventually. If not, I’ll have to eat my words. Luckily, they won’t taste of much.