Saturday 26th July 2025
Blog Page 967

Editing genes: Can we? Should we?

It’s the year 2116, and the last person to die from malaria did so fifty years ago. Genetic demons such as Huntington’s disease and cystic fibrosis—whose heritability was a scourge on the psyche of those with a family history—can no longer hold prospective parents hostage. We’ve cracked the problem of world hunger and started bringing species back from extinction. Humanity has never had it better.

This is our future, or at least it could be. All of this is possible through the newest revolution in science, a technology affectionately known as CRISPR, the latest and greatest development in the field of genome editing. It allows the genetic makeup of an organism to be altered by adding, removing or swapping letters in the DNA nucleotide code.

Although similar targeted editing technologies have existed since the 90s, CRISPR is special because of its unrivalled accuracy and speed. Critical to the process, enzyme Cas9 is often described as the pair of ‘molecular scissors’ that snip the DNA at the point of modification. The enzyme is guided by an artificially synthesised RNA molecule to the appropriate sequence in the genome, meaning that researchers can manipulate where Cas9 cuts through changing the code of this guide RNA.

Earlier this year the HFEA, the UKs Fertility authority, approved a request allowing use of CRISPR on human embryos, as long as all embryos are destroyed after seven days of development. This allows study of the earliest stage of human embryonic growth, a major landmark in the history of the technology.

CRISPR has the potential to represent the next step in human evolution. However, there are many who would prefer to remain in the present, or even to turn and run back into the past.

Arguments against genome editing take a primarily ethical route. Critics propose that the concentration of these technologies in developed nations would mean they would only be accessible to the most fortunate of our planet, creating an evolutionary gap in class. Furthermore, eradicating conditions such as Down’s syndrome could devalue the lives of those afflicted, portraying them as less than human. And many feel that power such as this should not be wielded by humans that we would be playing God.

Are these arguments relevant? Yes, of course. But they are at risk of missing the greater point.

Science itself is unprejudiced and unemotional. It is not in itself evil, but it can be used for evil. Therefore genome editing must be monitored on an international scale to ensure the fulfilment of its potential to do an incredible amount of good and minimise undesirable social side-effects.

Those who say we would be playing God should be reminded that we live in an artificial world forged by us for us. Humans created dogs, dams and cities. We’ve eradicated smallpox while harnessing natural energy sources to generate power. We are becoming increasingly more aware of the villains of the future, from climate change and antibiotic resistance to overpopulation, and taking control over our own genetic destiny should be the next stage in our defence.

Every generation has a duty to the next to decrease the suffering it itself faced from genetic diseases, and we have an opportunity to do just that, beginning with CRISPR.

Interview: Elspeth Garman

Elspeth Garman is a Professor of Molecular Biophysics in the Oxford Biochemistry department. Working at interface of all three core sciences, she has helped develope physical techniques in a field that has yielded 28 Nobel Prizes to date, unpicking the chemical properties of biological molecules. One of these techniques, cryo-crystallography, is now the principle method of protein structure determination worldwide. Elspeth told Cherwell about the Garman limit, misogyny she has faced in her career, and why, even after numerous awards marking her as a forerunner in her field, she is most proud of her graduate students.

How would you describe what you do to the layman in the street?

I like talk to all sorts of people that I meet on buses and in taxis and the way I explain what I do is find the three-dimensional shape of big, biologically important molecules—proteins, which are like strings of beads that wrap up like wet spaghetti. Why do we need to know the shape? Using insulin as an example, from knowledge of the 3D shape of insulin we have been able to see what’s on the inside and what’s on the outside [of this protein] and how the mechanism of glucose regulation works. From that shape it has been possible to make a synthetic insulin which is absorbed more slowly by diabetics, so they benefit by not having to inject so often.

The method we use sounds ridiculous: we grow crystals. The biological molecules line up like soldiers, but 3-dimensionally, so upwards as well. It’s not like a diamond crystal, which is hard and only has carbon in it, because we have gaps between our blobby molecules which have liquid in, so it’s like these soldiers are in a swimming pool. If they are removed they tend to bend and not stand to attention in same way; we rely on the fact that all the soldiers are standing to attention to get our [X-ray] scattering. We hit them with X-rays and from [the way X-rays scatter from the molecule] we can deduce the shape.

The actual growing of the crystal is more luck than good management. It’s trial and error. In a recent project we tackled, the tuberculosis enzyme, we set up seven thousand crystallisation conditions and we only ever grew one crystal which was only 23 microns [one fiftieth of a millimetre] in size.

I gather you are very instrumental in improving the techniques used rather than working on the results.

The things I’m known for is development of cryo-crystallographic techniques. Now nearly 90 percent of Protein Data Bank [the primary protein structure reference database] entries are determined like this. We plunge-cool the protein crystals into liquid nitrogen and then we collect data with a gaseous nitrogen stream at 100K [-173°C]. Why do we do that? Because we get on average seventy times more data at cryo-temperatures than we get at room temperature. At room temp you need tens of crystals because the radiation damage is so intense.

I [helped by] putting some systematic physics onto the problem, and we made a lot of gizmos. I found that my baby’s hair could make very nice loops [to hold the crystals]. It is quite difficult to tie the loops so I made a little machine which helps you do that, then we would loop the crystals, like bubbles, using surface tension of the liquid to hold the crystal in the loop, then plunge-cool it.

What my group looks at now is trying to understand the damage the X-rays are causing [to the proteins] to give people an idea of how many X-rays they can put on their biological sample before the information yielded is compromised. In 2006 we published a [seminal] paper which gave the experimental dose limit, embarrassingly called the Garman limit. It is great to have something named after you, it was the best experiment I’ve ever thought of and I’m very proud of the way my student and I did the experiment.

What makes you get up in the morning?

My graduate students. The greatest fun I have is with my graduate students. They give you three years of their life to study something you’re interested in; it’s an amazing gift! I feel a responsibility to make sure they network, do something positive, enjoy what they’re doing, get publications, can get a good job afterwards, and learn respect for the human race. In my view I owe them. All my research has been made possible by graduate students.

One hears a lot about the gender gap in science. Having spent your entire working life in science, particularly in physics, how much of an issue do you feel it to be?

It’s not changing as fast as we’d like and yes it is an issue. The problem in physics was I was the first female graduate student for fifteen years in the area I was in, so you bore the flag for all women-kind. If you did something stupid it was because women were stupid, not because Elspeth made a mistake. I found that difficult. And when I was younger collaborators and people who wanted to talk science with me got teased by the other men. I tended to just plough on. But there were advantages as well as disadvantages; the worst moment—the worst I can put on record anyway—was when I went to my first international meeting in Berkley, San Francisco with 992 men and eight women. The equal rights amendment had just come in in the States and the physics department had been told it had to recruit a female nuclear physicist. In five days I was offered twelve jobs, only one of which was a genuine ‘fit’ for my experience and research interest. It was the most demeaning, degrading experience—job offers just because I was female. Unfortunately in the States in nuclear physics a few women were taken on who shouldn’t have been, filling quotas rather than selecting the best candidate, and then subsequently more women weren’t welcomed as the earlier one had been no good. This back lash was quite serious and makes me very hesitant about positive discrimination, so I am torn.

It’s not really about being a woman in science, it’s about being a scientist.

Bah, humbug: An Oxmas Carol

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Michaelmas term fading on the winds of goodwill, tickling the spires in their sleep. Blackwell’s admitting nobody, but quietly shunning a few wayward party-goers. All Oxford seemed arrested in either expectant slumber, or festive fervour.

And yet, tucked away at the top of staircase nine was Edward Stooge, a miser in a youth’s body. While his surroundings throbbed with excitement, he paced his cramped cell, clad in his onesie of loneliness. Procrastination, that cruel spectre, haunted him there. A knock at his door brought him to his senses. How stunned was Edward’s friend Matthew to see such ghastly attire! His grin seemed to blurt out without moving.

“Eddie,” (Edward resented the nickname) “you are going to Lola’s tonight, right?”

Edward tried to excuse his own misanthropy, but Matthew’s dog-like loyalty was insufferable. He would not understand.

The door was thus slammed upon him, not without some force. “Suit yourself,” Matthew was heard to say, totally unaffected. “I’m gonna get sloshed. I’ll be seeing ghosts after tonight.”

With the chuckles retreating down the corridor, Edward retired to his desk, cackling, “Is this the meaning of Oxmas? Bah, humbug!” as he skulked. Yet it did affect him that in this time of repose and warmth he should be snowed under his work: not even the collective cheer of Broad Street could reach his window.

In a stupor of overwork, he fell asleep.

When next his eyes opened, there was a persistent knocking at his door. He was certain a ‘sloshed’ Matthew was playing a trick, so armed himself with a slipper. Then, suddenly, a ghoulish wraith forced his way under the door. He looked remarkably like Matthew, and borrowed his voice.

“Eddie,” his voice boomed with uncharacteristic urgency. “Let me show you your past.” The room was transformed into a nightclub Edward faintly recognised. The two stood, voyeurs to a more liberated player of Edward downing Jägerbombs to the rhythm of cheering crowds.

“Is that…” Edward started.

“Yes. Look upon but a term’s work, what it has reduced you to. Never will you rekindle that Fresher’s spirit.”

Edward tried to disguise his mourning.

The bedroom materialised as he protested, “We all have to grow up at some point,” but his defiance cracked mid-sentence. This ghost of Oxmas past needed only grin as he vanished into the aether.

Edward inspected his tea to see if it had been in any way spiked, before splaying himself out on the bed. “Hemingway and Earl Grey really do not agree with me,” he muttered drowsily.

Edward’s next visitor was too eccentric for the frippery of the door. This next phantom rapped at the window out of courtesy before phasing in. The fiend was unmistakably in the garb of Edward’s lecturer: shabby shirt, bowtie and all. Rearing his head, Edward feared the ghost might do what its visage implied.

“Edward Bartholomew Stooge,” hollered the ethereal academic. “Let me show you how insignificant insecurities be.”

The pair were lifted into a well-known auditorium, suspended above the stage. Though he stood where generations of superior intellects had inspired and blunted the imagination, Edward was bombarded with the thoughts of the audience, his peers. “What does this guy mean?”, cried one poor youth. “How will I read all my books?”, soliloquised another. “Does he really like me?”, “What am I having for dinner tonight?”

Trifles all! They were heavy burdens which satirised Edward’s own.

As the teacher deposited his pupil in his room, he said, “You are not alone, even in your petty concerns.” He determinedly made for the window, but an impulse stopped him. “One more thing: essay for Monday, no run-on sentences.” He took his leave.

Judging by the rule of three, Edward, alert, in the foetal position, was determined to be ready for the appearance of his final guest. This crafty poltergeist caught him off -guard still, by erupting from the floorboards. From his bright green chinos, Edward could not fail to identify the chaplain in this apparition. Edward refused to sit dumb. “What can you show me, then? Success? Love? Family? Disappointment? It’s hardly very Christian of you to appear in such a fashion.”

“I will pretend I did not hear that,” replied the chaplain. “And I can show you all of the above, if you neglect my words.”

To his surprise, Edward found himself not far afield, but in his very room. Something was amiss. Books began raining from the ceiling, clattering around his ears, sealing him in a hardback igloo. Outside his door, he could make out the laughter of his friends, an uproar which drowned out the simultaneous conflagration of his term’s work. The flames licking his skin, Edward begged forgiveness. And his call was answered.

In a cold sweat, Edward listened closely to the chaplain’s closing words. “We have shown you all we can. Think on your welfare—and come to Evensong on Sunday.”

Edward had what he wanted, to be solitary once more, yet it no longer sufficed, but created a hole: one which craved friendship, a desire work could not imitate.

Imbued with new purpose, Edward flew downstairs. His destination was that chaplain’s abode, the chapel. It was as if he knew the tower door would be open to him. Perched high above the dreaming spires, he sought to stir them with the most heartfelt “Merry Oxmas, Everyone,” a man could muster. In the avenue below, a drunken, home-bound Matthew returned his call jocularly, swaying to the symphony of bells.

Rewind: Miracle on 34th Street

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Beginning with the inevitable disappointment of my ‘Secret Santa’ present, followed by a festively violent round of musical chairs and reindeer ice cream at lunch, the course of the last day of the autumn term was the same every year. Then, back at home and revelling in the luxury of a half day at school, I’d slot in my old video cassette of Miracle on 34th Street.

Set in Macy’s department store, you’d be forgiven for assuming that the film would be soullessly, depressingly commercial. Even the nature of its release in 1947 points towards a penchant for mindless consumerism. Arguing that warmer weather would sell more cinema tickets, the studio-head of Twentieth-Century Fox insisted that despite being set at Christmas, the film should be released in early summer.

Indeed, the film reflects a sense of the creeping consumerism which had latched itself to the festive season over the previous decade. In 1939, the retailer Montgomery Ward created a character called Rudolph the Red-Nosed Reindeer in order to attract children to its stores. And only a few years before, Coca-Cola launched its advertising campaign featuring a fat Santa in a red coat, altering the public’s perception of Father Christmas forever and heralding the rise of the newly commercialised Christmas of the 20th Century.

“Make a buck, make a buck”—the mournful refrain of Alfred, the sensitive Macy’s employee, seems particularly apt in this context. The influential Catholic Legion of Decency went so far as to dub the film to be “morally objectionable in part”, primarily because Maureen O’Hara played a divorcée. But Macy’s is a far cry from the manger, and the wholly anti-religious department store setting can’t have helped.

But there’s something commendable about the shamelessness of the setting. It seems refreshingly honest, especially when juxtaposed with the dewy eyed sentimentality of today’s anxiously awaited John Lewis adverts, for example. Instead of shying away from the reality of modern Christmas by retreating to a quaint polar landscape, or indeed the moon, director George Seaton had the guts to embrace the frantic commercialism now synonymous with the festive season with perceptive wit and dry humour.

So I don’t necessarily subscribe to Alfred’s insight that “there’s a lot of bad-isms floating around this world, but one of the worst is commercialism”. After all, what could be more Christmassy than frenzied crowds of shoppers, hour-long queues and overdrawn bank accounts?

Graham Greene and Oxford’s pubs

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Have you ever had to down a few drinks to pluck up the courage to speak with someone you fancy, so intimidated by their attractiveness or by your own burgeoning emotion?

You’re in good company. One of the greatest British novelists of all time, Graham Greene, recalled his crush on a Lamb and Flag barmaid, “who we all agreed resembled in her strange beauty the Egyptian queen Nefertiti. What quantities of beer we drank in order to speak a few words with her”, in his Fragments of Autobiography.

Greene is known to have been a frequent face at the Lamb and Flag, off St Giles. Much like Gerard Manley Hopkins, the subject of this feature a few weeks ago, Greene was prone to bouts of depression and religious doubt both during his degree and during his life, affecting his relationships and work. He graduated with a second class degree, so clearly his skills as a novelist surpassed his abilities as an essay writer.

Greene was to write a number of books, both serious novels and what he called ‘entertainments’, after leaving Oxford. But even these lighter works, Brighton Rock and Our Man in Havanna being just two, were classics which explored twentieth century anxieties, through a lens of tortured Catholicism. It was during his time at University that he first tried his hand at creative writing, publishing a poorly-received poetry collection, Babbling April.

Pub-going authors abound, and when walking down St Giles from North Oxford, it’s sometimes impossible to make it into town without first stepping off the pavement to avoid the usual congregation of tourists crowding round The Eagle and Child. This was where the Inklings, a group of literary-minded friends and tutors which happened to include C.S. Lewis and J.R.R. Tolkien, met. Here, the literary worlds of Narnia and Middle Earth were dreamt up in hazes of revelry and creativity. Would that my own pub trips this Oxmas might be quite so productive.

A “tinsel-covered silver lining”

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It’s that time of year again: you can start bracing yourself for the onslaught of high-pitched jingles and ‘Christmas special offers’ designed to lure you further into the trappings of capitalist society as soon as you make your way into any shop or department store. The cheerful tunes may well be poison to your ears because you’re neck-deep in an essay crisis and not quite feeling the holiday vibes yet. This was me a year ago, and it’s not too far from where I’m at right now. Oxford has a knack for making it difficult to think beyond the present, but at least this time around, I know there will be the tinsel-covered silver lining that is Oxmas.

While Oxmas may seem like another branch of the broader commercialisation of Christmas, occurring months in advance of the actual thing and adding to an already rampant consumer culture, it is possible to enjoy Oxmas despite being generally critical of the premature holiday fervour because it focuses more on the communal aspects (Oxmas bop, dinner with friends) than consumerist ones. Admittedly, my fascination with Oxmas stems from my status as an outsider and the sense of foreignness in which Christmas is shrouded for me.

Before you start picturing a naive girl gawking at ornament-laden Christmas trees in wide eyed wonder, let me clarify that I was familiar with the cultural paraphernalia surrounding Christmas: I’d watched my favourite characters on TV unwrap presents and cosy up to watch It’s A Wonderful Life with their families (or not, in the case of poor Kevin). I’d read A Christmas Carol when I was a child but hadn’t particularly liked it. Every December, when my aunt, who lives in London, would visit us in Lahore, my younger sister would have a special request: “Can you bring some Christmas crackers with you pleeeeeeeeease?!!”

And so the crackers would come and in the relatively mild winter of Lahore we’d have our share of Christmas fun. Be as that may, I’d never seen it celebrated in the flesh before. The Christmas markets on Broad street may pale in comparison to the German markets my friends spoke about, but they were the only ones I’d ever seen, and the Nutella crepes I bought from there brightened up my otherwise foggy emergency treks to Tesco.

In the run up to the (free) Oxmas dinner, the weather becomes unbearably cold and grey, and as everyone duly cracks out their worn and well-loved Christmas jumpers (though this could be me romanticising what may well be recent purchases from Primark), I feel a little envious. I decide I want a cosy Christmas jumper too, and roam Cornmarket in search of one. But alas, the only remotely Christmassy jumpers I can find are either overpriced, unbearably gaudy or have Olaf’s face on them.

Week seven rolls around and you can see Christmas trees being carted around college. I’d never seen a real life Christmas tree before, and although I can’t say it was a life changing experience, I can now fully appreciate how horrible my five-foot self would be at decorating one. I was already familiar with the culture of festive gift giving: growing up celebrating Eid in Pakistan, the excitement of waking up to presents, albeit without the dramatic flair of them being positioned under a tree of the pine variety, was a familiar one. But where Eid normally involved visiting family and friends with the intention—for me at least—of coaxing Eidi, gift money, out of them, the markedly less commercialised nature of Eid means that we don’t have an equivalent of ‘Secret Santa’.

Nor, sadly enough, do we have anything like John Lewis Christmas adverts. When I first heard some friends having a heated discussion about their favourite—was ‘Man on the Moon’ trying too hard to be a tearjerker?—I was mildly amused, but when someone actually showed it to me, I must admit my heart melted a little. ‘Buster the Boxer’, in comparison, is looking like a bit of a disappointment and has managed to spark controversy already. Apparently keeping the Santa Claus myth alive for kids is important enough for some parents that they don’t want their children watching the father assembling a trampoline for his daughter.

Others have gone far enough to compare Buster to Trump, who snatches the opportunity to jump on the trampoline away from the more experienced and deserving young girl. Clearly John Lewis ads are no joking matter. Thankfully, we are told to keep our ‘Secret Santa’ gifts simple, so the ads are as far as my acquaintance with the John Lewis Christmas catalogue goes.

Oxmas bop is, appropriately, a blur. The dining hall is packed full of people on the evening of the Christmas dinner, and although I wasn’t a huge fan of the food itself, the atmosphere — probably fuelled by wine and the relieved realisation that this collective nightmare called Michaelmas would be over soon—was ebullient. The exuberant Oxmas cheer was a welcome light at the end of a long, cold tunnel and its location at the end of term meant that it glossed the gruelling work of Michaelmas in a warm haze, leaving me with echoes of Mariah Carey’s voice singing ‘All I Want For Christmas’ on repeat in my head.

On this note, I pack my bags and fly back home across continents, humming upbeat Christmas tunes and feeling oddly disoriented by their sudden absence when I arrive in Lahore.

If…everything was determined by referenda

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To tell you the truth, I don’t relish the idea of McDonald’s sponsoring referenda. First, it would greatly increase voter turnout. Recent polls suggested that turnout could increase from the standard four per cent to anywhere between fifteen to twenty per cent. It turns out that the draw of a free SuperMac will indeed have a marked impact, given that every voter got one free with their vote.

Of course, something had to be done. This four per cent average is the lowest in all of my five decades of counting experience (and my two decades of voting experience) before that. After all, four per cent was, what, four million votes? Ideally you would want a voter turnout of around sixty per cent, but counting up around fifty million votes was not a particularly attractive prospect for Britain’s few remaining vote counters. That the state employed us was initially a problematic concept, given that the demonstrations about possible vote rigging or misinformation spread away from the His Majesty’s Virtual Reality People’s Parliament (or HMVRPP for ‘short’) and onto the streets. For everyone watching the voting process or the news through their Headbook headset, I understand that to have demonstrations on the street is a shocking concept, but when I was a child, street demonstrations were regular, if not common. As a result, you can imagine just how panicked Government got about it.

At any rate, all the controversy blew away to such an extent where the voters went with it. But the referenda didn’t blow away—they kept coming with alarming rigour and frequency. I only finished my last count yesterday, but I expect to be back in the office tomorrow to count anew. I think that tomorrow’s referendum concerns legislation about waste management, or something. I forget. Maybe that was last week’s. Tomorrow’s could be the one about public listening of music, or about curfews. I forget.

I have been forgetting a lot recently, actually. I should probably retire, but apparently I’m “too valuable” to be let go. Apparently it’s rare to find someone so politically aware in someone so “experienced”. Ha! If they only had the nerve to tell me that my age makes me valuable, derived as I am from a time where they held elections, not just referenda. I do still remember General Elections. How quaint they seem now. It did always strike me as odd that someone would be voted in only for ten years of complaint during their party’s term.

Things are much simpler now since the dissolution of the European Union and the establishment of State Referenda. It certainly keeps the country’s bureaucracy ticking. In fact, we depend on them. I can’t imagine how The British Kingdom could claim to be democratic without referenda. Scotland, since leaving us, have no referenda at all—all their claims of financial security and social harmony must be a lot of hot air. No-one really knows what goes on over The Wall of Unity, of course. Ever since they voted leave in their fifth Independence referendum (the final one that they’d ever have) relations have been frosty. Surely they’re not serious about how good representative democracy is. It’s all just lies from their biased media.

Speaking of the media, I think it’s really disappointing that more isn’t done to shut up the young idiots who set up their own VR channels to pretend to be all counter-culture and unique, complaining about their ‘civil liberties’ and their ‘rights’. I never had their cheek when I was their age: I never demonstrated against welfare cuts, or the so-called “erosion” of democratic processes, and look where it got me! I have a hefty wage, job security, and a nice state exception from ever having to vote. In fact, McDonald’s sponsorship of referenda voting will do my chances of retirement a world of good: with more voters, they’ll have to employ more counters which will mean I can train up some new recruits, specifically chosen for their political impartiality—or apathy, it matters little—and then retire with cake, celebrations and a knighthood. Maybe they’ll even get me a gift of a new VR headset to live my soaps with. My old headset’s 10K display is so dated now.

Actually, come to think of it, yes, this sponsorship is excellent news. I can’t wait to see all the happy voters leave the polling station with their SuperMac in hand. I still think that voting should all be done over VR, but the traditionalism of a personal vote is quaint and reassuring, in the same way I was delighted to see all referenda about the deposition of the monarchy resoundingly voted down.

Of course, I do sometimes feel a pang of guilt about spoiling all those republican votes, but I feel that, in my line of work, sometimes the most important civil servant is the one who dots the is and crosses the ts—even if the letters themselves occasionally have to be added in. People like me, who loyally serve the country, are really key for social stability. These people who actually vote are idiots: they don’t understand their vote, and any cry they make of ‘democracy’ deserves to be ignored. Really, by being foolish enough to vote, they’re just part of the process themselves.

Profile: Nicky Morgan

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Nicky Morgan has had a rollercoaster year. In January, she was the unshakeable Education
Secretary planning a major overhaul of the education system. Her plans to turn all schools in England into academies have since fallen through.

She was asked to leave her post and the government by fellow alumna of St Hugh’s, Prime Minister Theresa May. The MP for Loughborough, who was at once seen as a potential future leader of the Conservative party, now finds herself on the periphery of of British politics.

She chuckles, “It’s ironic. Two women in the Cabinet who are both graduates of St. Hugh’s
College—one is Prime Minister and the other has returned to the backbenches.”

I do not expect her warmth and honesty, and she seems far more comfortable discussing
the difficult issues—like her “sacking” from the Cabinet or the government’s plans on grammar schools—than I had imagined. She is immediately keen to discuss Brexit. I ask her if she thinks young people in particular will feel the impact of the decision.

She asserts, “I certainly think there’s still a danger of young people being hit. What I was
referring to during the campaign was how many recruiters and employers would be reluctant to take more people on until they know how Brexit was going to work out.”

She discusses how the Chancellor’s Autumn Statement may clarify the issue of Brexit for
both her and the public, but adds, rather reluctantly, “You know, I think the honest truth is that none of us know how it’s going to happen.”

She does not just associate Brexit with doom and gloom, however, adding optimistically, “Ultimately, we are a great country—innovative, entrepreneurial—and we will recover.”

In light of the US election, I wonder like many commentators whether there is a comparison to be made between the referendum vote and Trump’s campaign.

She states firmly, “There are parallels. But we can’t take the comparisons too far. There is no doubt that there are many people who have been challenged by the changing world. In the Brexit campaign it was all about taking control back—I wasn’t entirely sure what that “back” meant. In the US election, it’s been about “Making America Great Again”—but many of us would argue that America is a successful and powerful country already.”

However, the former Education Secretary doesn’t shy away from the fact that politicians such as herself have to maintain trust with the electorate.

She explains, “We have to be very clear that some politicians have over-promised and under-delivered and sometimes we’ve said to people there are complex problems that can
be solved with simple solutions. I’m not sure we’ve been completely straight with people
about the complexities of what we’re doing.”

As Education Secretary, Morgan met thousands of young people across the UK. I suggest to her that the divisive nature of the EU referendum and the US election put young people off politics altogether.

She disagrees, “It’s really engaging young people—it’s not always positive—but it’s really
got young people talking about politics, talking about the US election and talking about the referendum in a way that I haven’t seen in quite a long time.”

Having been removed from the government so abruptly, her plans left unfinished, I wonder if Morgan regrets any particular point of her time as Secretary. She immediately raises one issue that she focused on during her time in office: the funding of secondary schools.
She says, “One of the things that needs to be set out is the funding of our schools. We
have 152 local funding formulae across the country, and that means that some schools are receiving a lot more funding per pupil than others, while we are asking all of them to do the same.”

I can sense the frustration building as she speaks. After all, she launched a national fair funding formula for schools only for May to say, in Morgan’s own words, “Thank you, but no thank you”. Her disappointment is visible. She adds, “I regret we didn’t get to publish the second part of that consultation and also I would have liked more time to put in place
bits of my white paper on education, particularly focusing on those areas where educational
underperformance is entrenched; and the way young people are just not getting the
best start in life which we as a country owe them.”

Discussing these mainstream subjects are interesting. Yet, Morgan’s passion, education,
is something that I want to explore further. It is evident that she has strong views on the grammar schools policy developed by Theresa May. I ask whether she opposes the reforms.
“Well”, she says, almost as if she is restraining herself, “It is currently constituted in the
consultation—yes, absolutely.” Morgan continues clearly and articulately, “We need to build a strong and consistent education system across the country. And my concern is, I know what departments and big organisations are like, if you have a clear policy direction and throw another policy development in and change direction, the people focus on the new, and don’t deal with what I think is the entrenched underperformance in certain parts of the country…that’s what needs to be focused on.”

Nicky Morgan appears to me to be an efficient, organised and well-prepared politician.
Having joined the Conservative Party at the age of 16, it comes as little surprise that she has “always” been interested in politics.

She played an active role on the Oxford politics scene whilst at university, standing twice for President of OUCA. She lost to fellow Tory, Daniel Hannan MEP, on the second attempt.
Yet, she isn’t the typical Oxford student hack. I was involved in OUCA; but for me the Oxford Union was the big thing. It was nonpartisan—certainly when I was here. but the debating, the ability to meet people—that broadening of horizons that actually says: yes, you can compete on a stage with lots of other people.”

Typically, she then adds that many of her fellow students “are now involved in politics on the national stage.” It is unsurprising that so many of her peers have ended up working in the same circles. It gets me wondering how many of the people I come to know during my time here will appear on the front pages of newspapers in ten years or more.

As we draw to the end of our time together, I feel that Oxford had a profound impact on
this MP, who is still hungry to make a difference.

When I ask her what the future holds, Morgan doesn’t give much away, smiling and saying “One of the things with a political career is that nobody knows what’s around the corner.”

Sci-fi review: Arrival

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Attempting to talk about this film without speaking entirely in superlatives is pretty tricky. Suffice it to say that Arrival is, right now, the best film of the year—and given that the year is nearly over, that’s high praise indeed.

The story follows Amy Adams as Louise Banks, a doctor of linguistics who is drafted by the army to help humans communicate with alien crafts which have arrived on Earth. Like the best of science-fiction, this premise functions as a backdrop for an intensely emotional and human story, a prism through which to examine the human condition.

This is the rare film which feels like everything has sprung from a singular vision. The score, the sound design, the production design and the cinematography come together seamlessly to communicate the story. The visionary in question is Denis Villeneuve, whose previous films include Prisoners and Sicario . If you’ve seen either of those films, you’ll know how brilliantly Villeneuve crafts tension, and Arrival is no exception.

The alien ships are worth singling out—Villeneuve holds off  from showing them until it really matters, and the ethereal, otherworldly first look is breathtaking and achingly beautiful.

Adams and Jeremy Renner do some careerbest work anchoring this film, giving subtle and understated performances that fit with the films muted, earnest aesthetic. Adams, in particular, surely has her Oscar nomination in the bag, giving a performance that’s both stoic and vulnerable in equal measure.

The film’s screenplay displays a similarly beguiling mode of “doublethink”, balancing the compelling, small-scale human drama with the global ramifi cations of the story. Much of the plot hinges on incredibly complicated neurolinguistic ideas, and the screenplay anchors these in intellectually and emotionally engaging ways.

One of the key ways it does this is with strong characterisation, demonstrated right from the emotionally devastating opening. The narration in this first scene jars slightly, but it makes total sense once the film is underway as it brings the viewer neatly into the melancholy realism the film occupies.

The final act is worth touching on. The film has a lot to say about the nature of language and communication, dealing with some quite complex ideas in extremely accessible ways.

That said, the film takes a giant narrative leap toward the end, aiming for some truly cosmic ideas. For my money, it just about stuck the landing. Though for others, I can see it being met with some eyebrow raises. But the unpredictability of the narrative was a rare treat in an increasingly formulaic cinematic landscape, and I can guarantee you’ll be talking about the film for days afterwards.

I saw the film just days after the results of the US election were announced. It was a week where it felt like no one was doing anything but screaming at each other. Arrival was the perfect antidote—a reminder that our shared humanity unites us far more than any differences of opinion divide us. A film that highlights the importance of communication and cooperation is exactly what the world needs.

Stanford’s different standards

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At Oxford, a student who writes well, speaks persuasively, and engages in critical conversation is considered “smart,” regardless of which college they belong to or what degree they are pursuing. The realization that this kind of liberal arts intellectualism is a central value here in Oxford shocked me. And that shock was deeply unsettling, because I realized I do not feel that way at Stanford. I do love the vibrancy of the Stanford community—the exciting fast-paced focus on innovation and progress. But my Oxford experience has revealed what is missing for me in Stanford.

First, the facts. Approximately 70 per cent of Oxford undergraduates read for humanities degrees. At Stanford, only 15 per cent of students major in the humanities. This difference speaks to an ongoing transformation in American education and culture: humanities programs, once the mainstay of a liberal arts education, now face a crisis of underenrollment at US universities.

Located in the heart of Silicon Valley, Stanford perhaps represents the extremity of a national shift in education towards science, technology, mathematics and engineering (STEM). In the New York Times article “Humanities Committee Sounds an Alarm” Jennifer Schuessler attributes the resounding decline in humanities majors to “the entrenched idea that the humanities and social sciences are luxuries that employment minded students can ill afford.”

I agree, in part, but students’ valid fears of job insecurity fall short of entirely accounting for the phenomenon at Stanford. Campus culture and social climate is impactful; at Oxford, academic culture plays a key role in keeping the humanities alive, whereas at Stanford, the laser focus on the quantifiable value of a college degree undermines the very legitimacy of the choice to major in a humanities subject.

The Stanford students I interviewed for this article agree that humanities students are often stereotyped and “othered” at Stanford. At best, the choice to major in the humanities earns regard as “interesting” while lacking in job prospects; at worst, humanities students are deemed frivolous and inferior.

Religious Studies and Philosophy double major Allison Zilversmit bluntly states, “Stanford is anti-intellectual.” She further postulates, “The humanities are dying at Stanford because they aren’t just a tool for your next job… they aren’t seen as having utility.” Kiley Samson, a Stanford Physics major, similarly commented that Stanford students consider the question “will this class be useful for me after Stanford?” above all else when deciding on their coursework, and by extension, their major. Lingxiao Li, a Math and Computer Science double major, agreed, adding that intellectual growth is not the central focus for many Stanford students. “I have friends who are like mercenaries,” he said, frowning. “They do not care about what they learn. They just want to get a degree and make money.”

These reflections echo the fear of job insecurity emphasized in the Times article, but also illustrate a regrettable cultural and economic sea change in how higher education is valued. Learning for the sake of learning, a once vaunted ideal, now seems quaintly elitist. While all the STEM students declared that the humanities remain important, they confirmed the dismissal and even denigration of “liberal arts intelligence” at Stanford, despite the university’s increased effort to celebrate and enshrine academic diversity.

Both Stanford students and Oxford students described a starkly different cultural and academic climate at Oxford. Owen Rappaport, a Classics major at New College, remarked, “in my mind, the fundamental part of Oxford intellectual life is around a dinner table.” This assertion underscores the importance placed on rhetorical ability at Oxford.

When I asked Walter Goodwin, a Biomedical Engineering major at Brasenose College, what sort of intelligence is highly valued here, he responded similarly with, “the ability to coherently create arguments.” He continued, “intelligence is someone’s persuasive logic based on their understanding of the topic under discussion.”

When comparing Stanford and Oxford, Zilversmit, a term-long Brasenose student like myself, agreed that Oxford students care deeply about intellectual discourse and rhetorical ability, while many Stanford students “don’t know how to disagree.” She reflected, “It’s really remarkable that I’ll be in class and start discussing something with someone and they will almost get off ended, as if I am contradicting their ‘right answer’ in favor of ‘my right answer.’ Ideally, the goal might never be about finding the ‘right answer;’ it is about engaging in discourse, and that engagement is the right answer.” Most Oxford students would probably agree with her.

Both Goodwin and Rappaport also noted how, compared to Stanford students, Oxford students seem far less focused on extra-curricular activities, resume building, and the necessary “applicability” of one’s degree. Goodwin observed that “in the States, the pursuit of extra-curriculars is given far more priority… and you have to do them rather artificially because it is almost a requirement [to get a job].”

Samson’s answer to the question “what sort of intelligence is highly valued at Stanford,” affirms Walter’s assessment. She described the epitome of intelligence at Stanford as “extra-curricular intelligence”—not only performing well in difficult classes, but also doing research and presenting it at international conferences, or founding one’s own business.

Some might be familiar with the 2015 Atlantic article “Rich Kids Study English,” which discussed a research group’s finding that “the amount of money a college student’s parents make … correlate[s] with what that person studies. Kids from lower income families tend toward “useful” majors, such as computer science, math, and physics. Those whose parents make more money flock to history, English, and performing arts.”

In the United States, students from low income and middle class backgrounds often face the daunting burden of student loans in addition to familial pressure to earn highly right out of college. Introducing the Atlantic article in the course of my interviews brought confirmation of such views. Samson asserted that, yes, wealthy students can indeed afford to major in the humanities because “they have something to fall back on,” a statement Zilversmit did not argue with.

Samson affirmed the researchers’ findings, commenting that “as someone coming from a lower socioeconomic background, I don’t think I could ever justify to myself the possibility of having two years without … a steady job or plan.” Both Goodwin and Rappaport commented that, while the “Rich Kids Study English” finding is probably to some degree true at Oxford, it is likely less significant. Walter explained that “the student loan system is so much more secure here that there is never any fear that you will be lumped with some kind of unpayable debt… there’s no reason to be afraid.”

So why are humanities important? Many argued that if we do not study the history, literature, and philosophy that form the cornerstones of our society, we risk forsaking consciousness altogether. But perhaps most unique and memorable was Goodwin’s testimony averring the importance of the humanities: “We have reached a point in technological innovation where the questions we need to be asking are again philosophical. Science and technology has solved so many of humanity’s problems, but now technology itself is becoming a problem, and that is a reality that humanities students and philosophical thinkers are going to need to tackle.”

I applied to Stanford as a likely English or History major, yet I declared to major in Human Biology. While I wish I could proclaim with full conviction that my decision was based entirely upon newfound interest and passion, I cannot. If Stanford’s undergraduate culture had encouraged me to feel that English and History majors are uniquely positioned to understand and thereby change the world, I likely would not have majored in Human Biology.

That said, I don’t regret my decision. I value the Human Biology Core, and had I not temporarily lost contact with the humanities, I might never have recognized their indelible importance to me. Thankfully, my time at Oxford has assured me that an education in the humanities will only increase my chance of contributing meaningfully to the communities where I work. Now, I must find a way to stay faithful to this creed back on the Stanford campus.