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Rogue ‘fat gene’ discovered

Oxford University’s genetics team has confirmed the existence of genetic variants, which specifically affect weight and fat mass.

 

This rogue DNA is apparently carried by more than a third of the population and can seriously increase a person’s chances of being overweight, obese or finding weight-loss and dieting difficult.

 

It was revealed that the presence of FTO, a gene discovered last year to affect obesity, worsened the effect of the newly discovered strand of DNA, leaving those with both at a far higher risk of morbid obesity.

Chilli spiciness measured

Oxford University scientists have devised a new way of measuring the hotness of chillies.

 

The process, which works by measuring the level of capsaicinoids (the source of the chilli’s hotness) in the chilli sauce, is called Adsorptive Stripping Voltammetry (ASV).

 

The present procedure for measuring the hotness of chillies in the food industry, using subjective taste testers, is considered far less reliable.

 

This new method can precisely determine the level of hotness more speedily and cheaply than ever before.

Modern life affects human identity

An Oxford University neuroscientist has written an article in The Daily Mail expressing her concerns for human identity in the 21st Century.

 

According to Susan Greenfield’s research mobile phones, video games and mood-altering drugs, which create sensory barriers between the human psyche and real life, are already seriously affecting the way our brains function.

 

Greenfield believes the apparent crisis of identity caused by modern living could affect the way that humans interact, behave and what we achieve.

Flies may be key to ageing

Scientists from Oxford University have discovered a gene in fruit flies that corresponds to the one in humans responsible for the Werner Syndrome.

 

The team, led by Dr Lynne Cox, found that when this gene is damaged in fruit flies they suffer a condition similar to the Werner Syndrome, which causes humans to age rapidly.

 

This development means that scientists may finally be able to evaluate the effect a change in the gene has to the human body as a whole.

Huge response to marrow drive

Hundreds of Oxford students flocked to a bone marrow clinic in Brasenose last Thursday to register as potential donors for graduate student and leukemia sufferer Matt Carver.

After being diagnosed with Leukemia in January, 22 year-old Carver has desperately needed a bone marrow transplant to save his life. The clinic, sponsored by the Anthony Nolan Trust, was organised to search for potential donors amongst fellow Oxford students.

Such clinics usually attract a maximum of 35 people, but Brasenose was inundated with around 250 students volunteering themselves. Even with ten people staffing the clinic there were long queues, and it had to stay open an extra hour and a half to deal with the response.

Over 120 ‘usable’ samples were collected on the spot, and further postal registrations will mean the number will rise further.

Charis Demetriou, a fellow Brasenose student who helped organise the event, said, “Great things happen in Oxford – it was awesome to see that people do care.

“Because of the strict criteria of the health conditions of potential donors many of them were not able to register, also students who don’t know if they will be resident in the UK for the next three years. But that doesn’t matter – what matters is that they turned up and offered.”

He added, “Many of the people that turned up were friends of Matt Carver, and others just happened to hear of the clinic. It was fantastic to hear people saying things like ‘I always wanted to do this but didn’t know how’ or ‘I just saw it on Facebook and thought I’d come along.’

“It was both refreshing and re-assuring to see Oxford students rallying behind a friend in need and making such big commitments in order to help a fellow student and others like him.”

According to Demetriou, Carver was “shocked and obviously very happy to see the support both from the college community and from people he never met in his life.

“It gave him such a huge boost to know that the student community is behind him.”

The clinic’s confidentiality rules mean that it is unknown whether any of the people who signed up were matches for Matt Carver, or for anyone else on the waiting list.

A spokesperson for the Anthony Nolan Trust emphasised that any students who are interested in becoming potential donors can still do so. Details are on their website.

There are currently over 7000 patients in the UK waiting to find a suitable donor.

Interview: John Barrowman

John Barrowman, entertainer extraordinaire, screen and stage star, is a fairly fine forty-something.

Classically handsome, he does occasionally suffer at the hands of the make-up department who have a penchant for orange foundation, and certain cruel friends of mine accuse him of looking slightly ‘plastic.’

When I meet him in the flesh (and fabulous flesh it is), Barrowman is radiantly beautiful. His skin glows, his eyes are luminous, and he is palpably alive; he looks little older than thirty.

How does he stay looking so good? ‘I drink two litres of water a day. I do drink alcohol, but not to get drunk, I don’t binge drink. If I’m sitting down to dinner, I won’t drink soda, I might have the odd glass of wine, but I’ll drink water.’

I’m sceptical; surely there must be more to it. ‘Well, if you ever need a little bit of help’- he tweaks the corners of his gorgeous eyes, and winks – ‘I’m all for it.’

He exudes vitality – and he certainly needs plenty of energy to keep up with his hectic schedule. But Barrowman doesn’t resent marketing his work. ‘I think of myself as a business – a product.’

After all, he points out, ‘If you become an actor, it’s always at the back of your mind: you could become famous. You shouldn’t pretend to be surprised or angry if it happens.’

This is a man who is booked until 2011 and is thinking even further ahead, planning a return to his first love, musical theatre – a genre he staunchly defends against detractors.

‘I’ve done “serious” theatre, I’ve done Shakespeare… I don’t see anything different about performing in musicals; to me they’re just as serious.’

Musicals are what Barrowman does best; he has appeared in numerous productions in the West End and on Broadway, including the National Theatre’s Anything Goes: ‘That was absolutely one of the most amazing experiences I’ve ever had.’

Currently in talks with Andrew Lloyd-Webber about a sequel to Phantom of the Opera, Barrowman’s also being wooed by Cameron Mackintosh, who wants him to play the title role in Barnum.

‘I’m inclining towards Barnum,’ he says. ‘It’ll mean getting back into serious shape, better than ever before. I haven’t been to the gym in seven months, I haven’t had time, I’ve been so busy with work.

But I’d have to do two months’ intensive circus training to do Barnum.’

Circus training brings to mind spangly, tight-fitting clothes, which would show off that rather fine physique to even greater advantage.

‘God, no, I won’t be wearing lycra,’ he exclaims in horror. And then, with a lingering touch on my shoulder and a glint in his eye, ‘Well, I’d be learning all the trapeze stuff and everything…I suppose maybe a pair of cycling shorts…Or they might even give me a leotard…’

Barrowman is the world’s most outrageous flirt, and delights in being provocative. Even his acting smacks of promiscuity: ‘Whenever I’m playing opposite a leading lady, or leading man, I have to fall in love with them a little bit, for it to be truthful, even if it’s not a romantic relationship.

I have to be in love with them.’ Women as well as men? ‘Yes, I never define myself – it’s unfair. Being gay, it doesn’t mean I don’t fancy women and think they’re beautiful.’

Yet this is all for show. He’s been with his partner, Scott, for nearly 15 years; they celebrated their civil partnership in 2007. ‘A civil partnership is not a marriage,’ Barrowman explains.

‘It’s about being recognisable to society and government, being equal to married people, it’s not actually being married.’ He objects to the terminology; for him, marriage has inescapable religious connotations.

‘Marriage means being part of an organisation that thinks I’m evil.’ He doesn’t just mean the Church. ‘It’s any religion really – they all want to get rid of me because I’m a gay man.’

The issues surrounding the societal acceptance of homosexuality are so important to him that Barrowman is currently filming a BBC documentary, The Truth About You, which aims to discover whether sexuality is determined by nature or nurture.
‘I’m undergoing loads of tests… I believe you’re born gay, but I think environment also has something to do with it. It’ll rock my world if we find out you’re not born gay, so I’m taking a big risk.’

Barrowman is happier about his big break, playing Captain Jack Harkness in the BBC’s Doctor Who and the susequent spin-off, Torchwood.

‘It was a little boy’s dream come true. If I only had to play Jack for the rest of my life, or for the next 15, 20 years, I’d be totally content,’ he says with a grin.

‘I don’t think of him as a character. He’s part of me. It was the easiest casting decision the team ever made; as soon as they saw me on the tapes they said, “That’s him!”’

John and Jack share many traits; they’re expansive and exuberant, and compellingly attractive. I ask how John feels about David Tennant; Jack certainly fancies the Doctor… ‘Jack sees that, I don’t. David’s not my type, he knows that.

We joke about it. People ask if we’d sleep with each other for a million pounds. We look at each other and go, “Ten grand, I would!”’

But if Jack’s a part of John, does that mean Barrowman never stops acting? ‘Oh my GOD!’ leaning forward for another firm but feeling touch on my arm, ‘of COURSE I stop acting!’

This seems rather dramatic, in every sense; I suggest he might be acting all the time. ‘God, no, I’m not acting now,’ with another caress.

‘This is the real me! Scott does say to me sometimes when I get home, ‘Come on, sit down, slow down, you need to relax,’and I do need to switch off. But you can always tell when I’m acting and when I’m being me. There’s a definite distinction. I’m a very real person.’

He may seem too good to be true, but Barrowman is real – I know, I saw him, I touched him, and will be dining out on the story for some considerable time to come.

I nearly ran him over on my bicycle on my way home, as he walked back to his car in the late-night drizzle.

I wonder if he would have come back to life? I like to think so.

I love charity

The greatest email I’ve ever read was about my penis. The first line asked if I was sick of girls saying ‘Oh! What a tiny penis!’

To me, this seemed odd as, depending on the viewer, this would either be serious professional misconduct or just needlessly tactless.

Apparently if I took some pills, women would then say, ‘Gosh, what a large penis!’ and then they’d want to sleep with me.

Which would again be odd; if a woman is to see my penis at all, she’s generally quite far through the decision-making process. I’m not just going to whip it out on the offchance, am I? Think it through, spammers.

My cock aside, the greatest email I’ve ever read was from the Proctors. Their latest one tells us that they’re not keen on trashings involving food.

So not keen, in fact, that they’re even willing to explain to us what ‘food’ is (apparently it includes flour, eggs and beans), just in case any of us had in fact spent the last two decades being nurtured in a sealed dungeon, fed intravenously.

Just in case we’d been in Oxford for at least six months, but still felt the need to ask, ‘Food? What’s that? I’m confused. Give me some examples. Do eggs count?’

Instead of buying this food, they say, we could all give ten quid to an Oxford charity, thus doing our bit to turn the city into a grins-and-candyfloss nirvana.

Traditions like trashing smack of privilege, you see, and in a city where hundreds ‘know you don’t want the Big Issue, but…’, we might as well all be pelting them with gold nuggets tied to bits of string, before pulling the gold back from their grasping, huddled masses like the dickheads we are.

Now, I love charity; I’ll get drunk to protest against even a mediocre genocide, and if a Big Issue does look good, I’ll download it.
My problem’s this: if there’s a list of people who can legitimately ask for cash to avoid looking privileged, officials of Oxford University will only be on it when we’re all surfing icebergs in hell.

In less than a month, the University is to ask donors for over a billion pounds. I’ll stick my neck out, and guess it’s not going on a soup kitchen.

The trashing rules generally make sense – but asking for our money? Who the blithering heck do they think they are?

Talking of wasteful traditions: if 3,000 of us gave the cash spent on subfusc to charity, we’d have ninety grand right there, minimum, and a better image to boot.

If they actually cared about inequality beyond as a tool to guilt-trip students, maybe they’d ask.

Let’s give some money, but not because they say so. Do it because we say so.

Because we do care, see?

First night review: Bald Primadonna

This, Ionesco’s first foray into that form of theatre we now call ‘the absurd’ could come across to us as just that in the usual sense – it is, and this production successfully transmits this, deeply funny. Ionesco did not find it so, however, and we cannot fail to feel the destabilizing effect of language which fails to engage with conventional speech patterns and a presentation of reality that refuses to obey mathematics or the rules of time.

That is not to say that this play is chaotic: in fact, as the clauses of the opening sequence show, it is so neatly constructed and so well balanced that the mundane becomes marvellous. The precision of the cast allows this to shine through. With their dealing of it each episode really clicks, even if some (such as the extended recognition scene of the Martins) seem a little too drawn out. Cater and Yusuf-George have moulded a production with truly excellent acting – each actor successfully emphasizes the extremity of their roles but with sufficient variation to avoid the risk of caricature. Take Mary for example, a role of great aggression and social expression sensitively performed.

They have a command of the language when it is at its most laconic or most extended: the Fireman, for example, makes his anecdotes evolve until in the final extended monologue the whole cast has welded to listen and comment so that each word seems vibrant and meaningful.

Alex Midha and Fiona McKenzie brilliantly play out the stereotypes that their names ‘The Smiths’ suggest, while making sure that every oddity of character, every bizarre element of their immaturity and conventionalism is played out; Tom Coates and Arabella Milbank give us a vibrant contrast. Juxtaposition of sexual and asexual, flows of speech with silence, anger with cheeky humour give us a highly concentrated play and a linguistic treat. Only at moments does a twinkle in an eye or a curve of the lip hint that they are having too much fun!

This is a play that makes so much of the incidental, whether its framework of an English lesson or a replay of a recognition game played by Ionesco and his wife. And the name? La Cantatrice Chauve was a slip of the tongue by one of Ionesco’s actors.

Ethical equity

As far back as 1970, the highly influential Nobel prize-winning economist Milton Friedman argued that for the benefit of society as a whole, the primary concern of business should be business, not social responsibility.

It is perhaps unsurprising that free-market economists such as Friedman and Smith would be dismissive of corporate social responsibility. What is interesting is that the ethical concern that may appear to be a contemporary phenomenon is in fact not a new consideration.
What has changed is the attention that it is getting. With NGO campaigns unveiling unethical business practices, and social and environmental concerns becoming important factors in consumer choice, corporations can no longer afford to dismiss their duty to the community.

The World Bank Group defines corporate social responsibility (CSR) as: ‘The commitment of businesses to contribute to sustainable economic development by working with employees, their families, the local community and society at large to improve their lives in ways that are good for business and for development.’

This extends beyond statutory obligations to comply with legislation. It also assumes that companies are accountable to the whole of society and not just to their stockholders.

A major motivating factor behind the recently heightened interest in corporate social responsibility has been the increase in consumer awareness and the emerging focus on the origins of products.

‘Fair trade’, ‘organic’, ‘sustainably sourced’, ‘ethically produced,’ ‘carbon footprint’: accreditations are multiplying and labels and packaging offer an increasing amount of information about how products are made and where they come from.

Books like The Rough Guide to Ethical Living and Oxfam’s The Good Shopping Guide provide detailed information on what brands to buy, which shops to shop in, which services to use, and, more importantly, which to avoid.

Corporations are aware of this increased interest: they want to avoid being pariahs like Nike or Wal-Mart, and they have also realised that having an ethical reputation is itself of commercial worth. Indeed, companies such as The Body Shop and Starbucks have built their brands (and client-bases) around their ethical practices.

Over the years, The Body Shop has initiated campaigns for women’s rights, fair trade, and HIV awareness, and against animal testing among other things. One of Starbucks’ guiding principles is to ‘contribute positively to our communities and our environment.’

It is impossible to enter a branch of either of these companies without being made aware that they take their social responsibility seriously.

This kind of ethical marketing is very much aimed at a lucrative, elite niche: affluent, educated, urban Westerners. Doug Holt, Professor of Marketing at the Saïd Business School, points out that this ethical focus is absent in business-to-business marketing, or in products aimed at consumers of lower socioeconomic standing.

During a recent talk Professor Holt argued that as well as buying into an ‘ethical experience’, consumers are also realising that ‘corporations have become the most powerful actors in society, so they need to believe that they are somehow constrained or doing good.’

Aside from influencing companies to adopt ethical practices to attract customers, the value of having this sort of reputation has also given NGOs leverage, which they can use to shape the behaviour and decisions of large corporations.

In a dispute over the trademarking of premium coffee, Starbuacks was forced to concede victory to the Ethiopian government in May 2007. Trying to trademark three types of coffee native to their country to improve coffee farmers’ revenue, the Ethiopian government ran up against the powerful coffee retailers’ lobby in the US.

These coffees were part of Starbucks’ premium line. Professor Holt assisted the campaign waged by Oxfam to aid the Ethiopian government, as he explained: ‘Starbucks had built up their brand into an ethical myth, but then they were doing something that could blow up in their face.’

By framing the case as an investor issue, with the negative coverage potentially destroying Starbucks’ ethical equity and thus putting the entire brand at risk, Oxfam and Holt managed to get the coffee retailer to back down. The Ethiopian government got its trademarks.

Of course public attention and consumer preferences affect only a very narrow slice of business. While consumers can choose to patronise a different coffee shop or buy a certain body lotion, they don’t choose between different types of copper based on the social responsibility of the mining company. Yet here, again, business incentives can push these companies to operate responsibly.

The NGO Earthwatch helps companies develop environmentally -sustainable practices, working with corporations such as Cadbury Schweppes, British American Tobacco and Newmont Ghana Gold. Whether or not the companies partnering with Earthwatch are genuinely seeking to be socially responsible, self-interested motives remain important.

Companies that work in tourism or natural resources are dependent on the environment and its resources to stay in business. They therefore have a clearly vested interest in the sustainability of their practices. Investing in developing sustainable practices can also be lucrative in an unexpected way, as there is now a market to sell such innovative techniques to other companies.

A number of companies that Earthwatch works with also invest in conservation capacity-building in developing countries where they operate. By building up the skills and knowledge of members of the communities where they mine, grow or extract they are contributing to their long-term prospects in those areas.

Furthermore,in certain other sectors, such as construction, companies known for respecting and surpassing environmental regulations are awarded contracts by planning commissions.

Claire Lippold, of Earthwatch, explained that her NGO works with even the most controversial companies as they are the most important ones to push into adopting sustainable practices.

More importantly, their partnership with Earthwatch isn’t merely ‘Greenwashing’: ‘We have very strict screening process and companies have to prove they are serious about their commitment before we get involved with them.’

Indeed to get the full commercial benefits of social responsibility, corporations cannot simply pay lip-service to ethical practices. Both the FTSE and the Dow Jones have sustainability indexes with which they track the financial performance and social responsibility records of ‘sustainably driven’ companies.

This serves to facilitate investment in these companies and to set a model for other businesses hoping to improve their scores.

While Milton Friedman may have dismissed corporate social responsibility as a form of socialism, what he seems to have missed is that in many cases ethical practices are not merely altruistic but also make sound business sense.

To quote his own words: ‘The most important single central fact about a free market is that no exchange takes place unless both parties benefit.’ This is perhaps the idea that provides the most hope for corporate social responsibility.

That businesses will eventually see that being ethical is to their benefit.

Douglas Hurd

Lord Douglas Hurd was one of the most influential Cabinet politicians in the governments of both Margaret Thatcher and John Major.
As Secretary of State for Northern Ireland from 1984 to 1985, Home Secretary in 1985-1989 and Foreign Secretary between 1989-1995, he oversaw the signing of the Anglo-Irish Agreement, the end of the Cold War, the disbanding of the Soviet Union, and the first Gulf War.

Born in 1930 Hurd is now retired from front-line politics, although as a member of the House of Lords, President of the Prison Reform Trust, a Patron of the Tory Reform Group, and a novelist who also has several business appointments, he is hardly ‘retired’ in the usual sense of the word.

His latest book is a biography of Robert Peel, the 19th century politician and founder of the modern police force. I ask him whether he likes writing better than he liked politics. ‘I like having something to write,’ he replies.

‘I’m writing a book about British Foreign Secretaries, and I’m enjoying doing that very much… I might go back to writing a novel, but at the moment I’m into history. History’s fun. In a way a novel’s more hard work, you have to flog your imagination the whole time.’

During his time in office, Hurd helped to promote good relations between Britain and the US, then led by George Bush Snr.

When asked whether he thinks that Britain’s special relationship with America is a good thing, given the unpopularity of the Iraq War, he muses: ‘Well, the Iraq war is wrong and foolish and we made a big mistake in getting involved in it. We’re a junior partner with the United States, and we have to learn how to do that properly. We’ve lost the art at the moment, and we have to find it again. Being a junior partner means you’re supportive but you’re not a slave. The partnership remains important…but it doesn’t mean just falling over and doing whatever they say.’

Hurd’s autobiography, Memoirs, revisits his opposition to military intervention in Bosnia in the early 1990s, and I wonder whether today he would make the same decision again. ‘I’m sure we were right not to try and impose a solution by force,’ Hurd concurs.

‘You can’t bomb people into peace. I’m sure we were right to have an arms embargo. Whether NATO could have intervened a little bit earlier than it did, say in ‘94 rather than ‘95, I’m not sure. The moment you intervene, you kill a lot of innocent people.

With hindsight, maybe. You have to be absolutely sure that you’re going to produce a better situation – at the time, we judged that we would not.’

A political moderate, Hurd has had a contentious relationship with those further right than him in the party. He has ‘disagreed with Norman Tebbit on most subjects under the sun’.

‘Well,’ he explains, ‘You have to work with people who don’t agree with you on everything, that’s what politics is about. I worked very successfully with Margaret Thatcher. We had one or two arguments, but it was a good relationship. Equally with Tebbit. I disagreed with him over Europe, particularly after he left the government. But that’s what politics is about. You disagree on some things and agree on others, but have to work with other people.’

He is also quoted as saying that ‘people are very interested in politics, they just don’t like it labelled politics,’ so I question him about how to make the subject appealing to the public. Hurd believes that the Conservatives today have become increasingly skilled at this.
‘Politicians have got to talk about the things that interest people in a way that people understand, and that’s what David Cameron’s trying to do, and I think he’s been quite successful. It’s wrong to say people are bored with politics – they’re just bored with the issues being treated as party politics.’

On the subject of David Cameron, I ask Hurd whether he thinks the Tory leader has lived up to his promise to change politics, making it more ‘grown-up.’ I also ask whether he thinks the Conservative Party is changing, and whether they will win the next election.

His take: ‘It’s certainly changing and our position is improving, and it’s improving because he changed the way he talks, the things he talks about, and more people are becoming interested. He’s in now with a very good chance. I would like to see politics become more local. I’d like to see people voting for a Member of Parliament as an individual and not just because of his or her party label. So that Members of Parliament are more important in their own right.’

As President of the Prison Reform Trust, Hurd has declared that ‘prison is just an expensive way of making bad people worse.’

British prisons are notoriously overcrowded, and Hurd thinks that a better solution is ‘to prevent crime. People who are sent to prison are mostly young people, they are people who’ve failed in education, they’ve been excluded from school or they played truant, they can’t really read or write, they get into drugs or they get into an argument when they’re drunk….

‘You’ve got to try and operate at the first stage, before they get into this drink and drugs situation. And that’s not something the police can do, it’s something the parents have to do. Once you do get into crime you’ve got to find other ways outside prison of punishing people.

‘I think the community sentences are the right approach but we haven’t yet found the kind of community sentences that the magistrates and judges think are sufficiently hard. The newspapers are always pressing for harder sentences, and I wish they’d spend a little time visiting prisons to see what happens.’

Against the apparent lawlessness of modern youth, Hurd promotes social institutions like the Church of England, of which he is a lifelong member: ‘The Church of England is the most important voluntary society in this country. The fact that it’s not as powerful as it was is used to make us forget.’

He describes it as ‘the only sort of community institution that works. The voice of bishops in the House of Lords is important. It shouldn’t be overwhelming, it shouldn’t suppress other points of view, but yes, of course, there is an ethical input into most of these problems. Certainly into war and peace. Capital punishment. At heart, they’re all moral questions. So the Church has a perfectly legitimate right to express a view.’

At Oxford University the Tory Reform Group has already merged with OUCA, but Douglas Hurd, a Patron of the national TRG, asserts that there is still a role for the organisation: ‘I think it’s important in some places, where you’ve got divisions in the Tory party – it’s very important that the One Nation view is powerfully represented. In some places you need a Tory Reform Group, and that’s why I support it. Cameron has moved the party in a One Nation direction, and that’s a good thing.’

Finally, in light of his most recent book, Hurd comments on how modern politicians compare to Robert Peel. ‘It’s a different world. The media are much more important now, politicians spend much more time dealing with the media, and that’s both good and bad, but it means taking the right decision is a lot more difficult. House of Commons has fallen into a pit in terms of what people think of it, and getting the House of Commons out of that pit is hugely important, perhaps the most important thing that politicians have to do.’

Now that he has left the Commons, this is not something that Hurd has to worry about himself; he can leave it for his successors, Cameron and Brown et al., to ponder.

Nevertheless the evidence suggests that Douglas Hurd will be an active figure in politics for some time yet.