Sunday 8th June 2025
Blog Page 281

Paxlovid: How a new oral drug against COVID-19 was designed

0

Despite progress with vaccinations, the highly contagious Omicron variant has caused cases to surge. Along with other UK approved drugs such as Merck’s Molnupiravir, Pfizer’s oral treatment, Paxlovid, could be a useful tool for doctors to treat patients. This antiviral was highly successful in clinical trials: compared with a placebo, it reduced the risk of hospitalization or death from COVID-19 by 88% if given within 5 days of the onset of symptoms. But how does it actually work?

Viruses are famous for having incredibly compact genomes. This allows them to replicate quickly and squeeze into a tiny capsid. One technique they use to achieve this is to store most of their proteins inside one gene ‘reading frame’ with no space in between. The product of this gene is like a long string of sausages, and it must be cut up into pieces by an enzyme called a protease.

Paxlovid is a ‘competitive inhibitor’ of this protease. It binds to enzyme incredibly strongly and blocks off the active site from cutting up the polyprotein. The Coronavirus can no longer express any proteins and will not be able to replicate.

On 13th March 2020, a Pfizer researcher in Massachusetts USA called Dafydd Owen was sent home from work. But he didn’t have time to sit around binging Netflix. “We were all sent home on that Friday, and the world was completely different,” he says.

Over the weekend, Owen and his team laid out a plan to resurrect an old and forgotten molecule and re-engineer it to be an oral drug against COVID-19.

In 2003, researchers at Pfizer had discovered an antiviral compound that blocked the SARS-2002 coronavirus protease. Owen was tasked with designing a molecule that could be taken orally and efficiently absorbed into the bloodstream – without changing it too much that it could no longer inhibit the protease.

A key alteration to the 2003 compound was the formation of a hydrophobic ring that was strategically placed to cover up a super hydrophilic area. “Making rings is kind of boom or bust in medicinal chemistry.” Owen says. “You either win big or you lose big.”

Another important change was the addition of fluorine atoms. This makes a molecule more ‘lipophilic’ and able to cross the cell membrane more quickly. This strategy has proven so successful that over 20% of pharmaceuticals are now fluorine based.

On September 1st 2020, Dafydd’s team received the results of their study in rats and it proved the nirmatrelvir drug could be administered orally, and still act as an effective protease inhibitor.

A phase 1 clinical trial on humans began in February 2021, a remarkably speedy outcome for a process that usually takes a decade.

“We need to show that antivirals still have real benefits for these people,” said Eddie Gray, chair of the UK government’s antivirals taskforce.

This data will be provided by an Oxford University study, called Panoramic, which is assessing the impact of antivirals on vulnerable but vaccinated people in the UK.

Image: Matthew Clark

Oxford SU continues boycott of National Student Survey

0

The Oxford Student Union has launched its annual boycott of the National Student Survey (NSS).

Since 2005, the NSS asks final year university students in the UK about their education, work and wellbeing experiences every year. The anonymous survey, under the guidance of the Office for Students (a third-party regulator of higher education sponsored by the Department of Education), includes questions on student learning, career, internships and placement supports, and general wellbeing. 

A notable absence from this year’s survey, compared to the past two, are questions relating to how COVID-19 has affected students’ experiences. 

Results from the NSS inform the commercially-produced University League Tables and are shared with universities and the public.

A main point of contention in the past, and the motivator for starting the boycott in 2017, was the survey’s links to the Teaching Excellence Framework (TEF). Historically, the TEF could have permitted higher-performing universities to charge above the £9250 fee cap. 

In part due to the success of boycotts across the UK, mostly in Russell group universities, the TEF is no longer linked to fees. 

Furthermore, a tuition freeze was put in place by the government in 2019. However, Safa Sadouzi, SU VP Access and Academic Affairs, notes that “while the future of government policy remains so unclear, we must send a strong message that we will not take part in this marketised point-scoring until we have more clarity on the future of the higher education policy.”

The SU also claims that competition fostered by the survey and league tables encourages universities to fund quick-fix solutions in order to improve perceived student satisfaction without tackling root causes. As well, past data has raised a variety of questions, notably regarding the survey’s negative appraisal of minority academics and innovative teaching.

A successful boycott of the NSS requires fewer than 50% of a university’s final year students to respond to the survey, and less than ten members of each course. This year, the SU hopes that Oxford will meet this target for the fourth time. 

As Sadouzi states, taking part in the boycott is quite simple: “Just ignore the emails and phone calls from [theNSS] and encourage others to do the same”. 

Those who have already filled out the survey can still rescind their responses by emailing the organizers of the NSS.

Anvee Bhutani, SU President, underscores the importance of participating in the boycott, as it “not only affects [current students] but also those who may become students in the future”. The SU highlights that there are already a variety of alternative surveys at the University, department and college-level, including the Oxford Internal Student Barometer. Furthermore, other platforms allow students to voice their concerns and provide feedback on their university experience, including the SU itself, common rooms and subject reps.

The survey closes near the end of April and results are typically published in July. It is at this stage that the SU will see whether they have met the 50% threshold and completed a successful boycott.

Image: Danny Chapman/CC BY 2.0 via flickr.com

70% of 2022 offers made to state-educated students

0

The University has announced that for the 2022 incoming class of students more than 69% of offers to UK applicants were made to students educated in the state sector. 

In last year’s admissions cycle, state school students received 68.7% of all offers, with 69.1% receiving them the year before. The percentage has remained consistently higher since state school students constituted 59.1% of offer-holders in 2016. 

The University announced that it ‘remains committed to offering fair access to all candidates, and early indications are that admissions from under-represented social groups continues to grow in line with last year’s figures.’ Last year, the state school admission intake hit a record high of 68.6%

The University’s Opportunity Oxford scheme – which offers students from under-represented backgrounds the means through which to transition to study at Oxford, including a residential stay in the lead up to their first term – is now entering its third year. Offers to the scheme have increased by 36.5% and have been made to 228 students. 

This news comes as more than 3600 students received offers of places for undergraduate study on Tuesday, the 11th of January. This is 2.6% more offers than were made last year, and means that 38% of the more than 20,000 students interviewed received offers. 

Oxford Farming Conference tackles sustainable farming

0

The 2022 Oxford Farming Conference, titled Road to Resilience, was held online from 5 January to 7 January. Industry leaders, activists, and politicians convened to discuss new approaches to building sustainable and resilient farming practices amid deepening economic and environmental challenges in the United Kingdom and globally.

UK Agricultural Ministers, including George Eustice, England’s Secretary of State for Environment, Food and Rural Affairs, and his counterparts from Wales and Northern Ireland, laid out their plans for government support for new approaches to farming.

The programme also included a session on the opportunities in farming and the food economy to contribute to the United Kingdom’s net-zero commitments. Farmers find themselves in the middle of emissions debates, with climate change poised to bite into crop yields and the agricultural sector contributing up 10% of total greenhouse gas emissions from the United Kingdom in 2019.

The conference also tackled lessons that pandemic-related supply chain squeezes carried for the future of global farming practices. The global agriculture trade keeps agriculture economically viable, according to participants, and new approaches to keep open supply lines and trade routes are vital in times of disruption.

Specific features of the programme included a lecture entitled ‘Hero or villain? How farming holds the key to net zero,’ a talk from the OFC Honorary President, HRH The Princess Royal, Princess Anne, and a conversation between Dame Ellen MacArthur and OFC Co-Chair Sarah Mukherjee MBE on navigating towards a nature positive food system. 

The session was conducted entirely online due to fears about the spread of the omicron variant of the coronavirus in the United Kingdom. The conference has been held annually in Oxford since 1936.

Image: Dan Meyers

EXCLUSIVE: Slavoj Žižek, Maisie Peters, and Peter Thiel to speak at Oxford Union

Ahead of the official release, Cherwell can exclusively reveal the Oxford Union’s speaker and debate line-up for the coming term.

The Union, which is hosting its first speaker tonight (January 18th), is set to receive the likes of pop star Maisie Peters, controversial Marxist philosopher Slavoj Žižek, and the Silicon Valley billionaire Peter Thiel, along with Edward Enniful, Editor in Chief of British Vogue.

Thiel, who will be visiting on the 23rd of February, co-founded Paypal and was an early investor in Facebook. With an estimated net worth of nearly $3 billion, he has invested in research into machine intelligence and combatting the effects of aging. He has achieved notoriety as a political activist, donating large sums to politicians such as Donald Trump and Ted Cruz. A recent keynote speaker at the 2021 National Conservatism conference, he is close Curtis Yarvin, an American blogger who has been described as “neoreactionary” and espouses the replacement of American democracy by monarchy or corporate governance.

Dame Sally Davies, the former UK Chief Medical Officer, will appear online on the 9th of February. She was appointed the UK Special Envoy on Antimicrobial Resistance in 2019, which was also the year she was appointed the first female Master of Trinity College, Cambridge.

Another speaker appearing online is Robert Mazur, the US Special Agent who played a key role in the takedown of Pablo Escobar’s cartel and money-laundering empire.

The Union will also be hosting Amika George MBE, whom TIME listed as one of the 25 most influential young people in the world. Aged 17, she started a campaign which successfully persuaded the UK government to provide free menstrual products in English schools from January 2020.

Whilst largely steering clear of politicians from the Anglosphere, this term’s other speakers are not apolitical. With the Saudi Ambassador to the United Kingdom and the Stavros Lambrindis, the former Greek foreign minister who is currently the EU’s ambassador to the United States, the Union looks likely to host contentious discussions. Lambrinidis’ visit comes soon after an essay by Boris Johnson arguing for the return of the Parthenon Marbles to Greece was found in an edition of the Oxford Union’s magazine Debate.

More broadly, the list of speakers seems set to appeal to many interests. Max Fosh (British Youtuber),  Dr James Green (NASA chief scientist), Maisie Peters (Singer-songwriter), Zak Brown (CEO of McLaren Racing) and Chamath Palihapitiya (billionaire financier) represent just a few of the many appearing in the chamber. The format will again be a mixture of In-Person and online events, with many of the international speakers appearing over Zoom. Two speakers  who will be appearing online are Professors Daniel Kahneman and Oliver Hart, who won Nobel Memorial Prizes in Economics in 2002 and 2016 respectively. Kahneman wrote the best-selling popular science book Thinking Fast and Slow, and is known as a pioneer in behavioural economics.

Beyond speakers coming for individual events, the term will again feature weekly debates, special events and Union Socials. Week five will see “This House Would Move Beyond Organised Religion”, featuring the Most Revd Dr Eamon Martin KBE, Archbishop of Armagh and primate of Ireland. The latter has made statements which have attracted controversy in the past, including a warning that any legislator who clearly and publicly supports abortion should not receive Communion as they are excommunicating themselves. Speaking in opposition to the motion he will be facing Imam Monawar Hussein, incoming High Sheriff of Oxford, Rabbi Dr Jonathan Romain MBE and Professor Linda Woodhead MB.

Other debate highlights include “This House Welcomes The New Era of Porn” featuring Love Island star Megan Barton-Hanson, and “This House Would Abolish Prisons” featuring US Court of Appeals Judge Thomas Griffith in weeks four and six respectively.

The first special event will be held in week two; end of January will see a panel on Holocaust Memorials, reevaluating how we commemorate genocide amongst new generations and a world rife with antisemitism. Other Special events include ´Women in Climate Tech´ and ‘Gown Over Tails: Women Who Shaped Union’. 

On the social side, the Union will hold a culturally diverse set of events, including a Lunar New Year social and Holi Social. A few other lighthearted socials include Film night, Jazz night and the Street Food Festival and identity-specific events such as a “Women’s and Non-Binary Debate Night’ in celebration of International Womens Day and a LGBTQIA+ Debate night.


Molly Mantle, President of the Oxford Union, told Cherwell: “I am incredibly proud of the Term Card my committee and I have put together and I can’t wait for the next 8 weeks.”

Image: Rich Viola/CC BY-SA 4.0 via Wikimedia Commons

Oxford, “Cycling City” of our world

0

Guilty petrol-fuelled cars drive past the sign ‘Welcome to the City of Oxford. A Cycling City’ every day. Little has been done to stop this reckless attempt at invasion. Yet, the city itself has maintained its sustainable and healthy green-green-green image. Anywhere between Worcester College and the roundabout (most of which is famously a Zero Emission Zone), cars are rare. Cyclists are everywhere, flashy E-Scooters swagger around, “helmet-on!” and “get-some-lights!” hecklers stand by Sainsbury’s Local 24/7, electric-powered buses take enthusiastic Brookes students down to Westgate, a man rides a gigantic unicycle past Magdalen Road Tesco Express every now and then, and pedestrians sneer at gullible tourists who bought a City Sightseeing bus tour around the city centre. The only welcome extraterrestrial modes of transport are the ever-useful Oxford Tubes and trains. When within the Oxford bubble, the very thought of cars, planes, those stinky gas vehicles is hocus-pocus gobbledygook. Clean, efficient Oxford leads as the example to the world’s costly and pollutant transport networks. 

That is, within the flat valley that spans somewhere between the god-forsaken roundabout and far treks beyond the train station. Oxford is not just the colleges and the University, but it is a city that is home to well over 100,000 residents. Besides, if you’re up in Cowley like I am, you will know that the three-way choice to East Oxford is not all smooth riding. The cycle up Headington Hill is a cruel Tour-de-France sweat-off. The gradient up Cowley Road is acceptable, though still gruellingly unpleasant and unpredictable after a long day’s work, not to mention the sheer number of crossings. Iffley Road is the optimal route up, may it may be a serious detour for some. At some point over the course of many upward journeys, you may start to realise that your slightly shady £40-deal bike is facing its limits. Or maybe that’s just my £40 bike deal. Even so, while your fitness levels may surpass the average of the university’s croquet team, the English weather is sure to guarantee some wet n’ wild surprises throughout the year.

That may sound cynical, but such petty frustrations with bike travel suggest why cycling can only ever be so popular among populations. The pandemic was supposed to be a unique opportunity to transform metropolitan cities around the world into metropolitan parks. Sneaky hills may be but one of the several reasons why cycling has not grown as much as it should have. Other reasons may include potholes (@Oxford City Council, please fix the two deep potholes at the top of the High Street, thank you), poor cyclist protection from cars, terrible lorry drivers, and possible drowsiness from the scents of car exhaust. If only we could be riding horses and chariots like in the good old days, huh?

Public transport exists. Hop on Oxford buses which (explicitly) only accept Brookes student cards and **not** Bod cards. Pay nearly £3 for a journey that you could have used to cop yourself a Tesco meal deal. The stealthy parasite that is public transport payment is mentally draining. Plus, given the infrequency of some bus routes, the narrowness of gaps buses often have to squeeze through, and the awkward limb-shuffles your body makes when making eye contact with other members of the general public, waiting on a bus in traffic is not very enthralling.

I don’t particularly like buses much but they do get you around, and they are probably the environmentally sustainable way to go for most cities and towns around the world. Tube services like the London Underground are similarly crucial for metropolitan cities to cleanse themselves of toxic fumes, but they are also expensive and not suited to all kinds of cities. Trains are just expensive, really. 

The elephant in the room when discussing environmentally sustainable modes of transport are planes. They are planet killers, but air travel provides a unique experience not many, if not any, other modes of transport can offer: everyone faces the same way, the sound effects are soft on the ear, the views are always spectacular, there are helpful assistants ensuring you are safe and happy, and, oh yes, they connect people from across the globe. In this age of Brexit, Zoom, and Black Mirror, international travel is as important as ever in keeping the human population sane and cohesive. If Earth is at odds with planes though, then we all are, unfortunately.

That brings us to cars. Cars’ glamorous allure is still too much for the sinful man. One’s control of the road, the radio, and the service station reflects one’s independence and authority. You are in charge. You are supreme. If you do not have a driving licence, you are weak, unworthy, even pitiable. Haha!

Luckily, electric cars are soon coming to a garage near you. From 2030, there will be a ban on selling petrol and diesel cars. God save the Queen. We all will live. 

However, more environment-linked problems may arise in the future from the production and use of electric cars. Several problems regarding high costs, lithium waste, and charging points have not been resolved yet. So, do I buy some Tesla shares or not?

The question is whether it has all been left too late. The answer tends to be yes, we most certainly have. While we’ve been dilly dallying away at playing war and what not, the planet’s climate has been getting on with ‘changing’. Transport accounts for over one fifth of the planet’s carbon emissions. Good thing that I got my ‘Walk to School’ badge in primary school, bringing the percentage down that little bit more. 

At the beginning of every Oxford term, like hundreds of other students, I am in one of those guilty cars passing by the ‘Cycling City’ sign. This awkward paradox–  driving into Oxford- ‘a cycling city’, never fails to confuse me a little. How else do you expect me to take 10 boxes of clothes, books, folders, pans, tea sachets, toilet paper, shampoo, a bit of booze and a dramatic amount of football memorabilia in and out of the ‘cycling city’ every term?

ÁWá/ CC BY-SA 3.0 via Wikimedia Commons

Oli Hall’s Oxford United Update – W1

0

It’s been a rollercoaster week for Oxford United.  It started off with the incredibly exciting news of plans for a new stadium but ended with a disappointing defeat for the men’s side away to Wycombe Wanderers that saw them fall out of the play-off places.  Elsewhere, the women’s side triumphed against Cardiff City.

On Monday the club published a statement on their website that provided the long-awaited news about the U’s future home.  With the agreement coming to an end at the Kassam Stadium in 2026, fans had been eagerly awaiting an update.  Their patience was rewarded with exciting plans for a club 18,000-seater stadium near Oxford Parkway complete with other facilities for the local community such as an ice ring and conference facilities.

Off the back of the news the away end was sold-out and in fine voice in Wycombe on Saturday.  Unfortunately, though United couldn’t capitalise on the chance to pick up some huge points over their rivals and sunk to a 2-0 defeat that saw the home side leapfrog Sunderland and Rotherham to go top of the table in League One.

It was over to the women on Sunday as they welcomed Cardiff City Ladies to the Velocity Stadium.  The U’s maintained their 100% home record so far this season with a sensational 2-0 win.  A Beth Lumsden brace with goals in each half saw a dominant Oxford maintain their promotion push and move within six points off Ipswich Town at the top of the table.

Looking ahead, the men’s side will look forward to a huge clash against Sheffield Wednesday at home on Saturday.  A win could see them back up into the play-off places and put some key distance between themselves and their rivals.  The women’s side will look to continue their sensational form when they welcome a struggling Chichester and Selsey.


Match Report: Wycombe Wanderers 2-0 Oxford United

Oxford United are still searching for their first league win of the year after sinking to a second consecutive league defeat for the first time this season at Adams Park.

After last week’s defeat the U’s fans were in fine voice at a sold-out away end in Wycombe, bouncing off the back of this week’s stadium news and happy in the knowledge that a win could lift them up the table.  It wasn’t to be though for Karl Robinson’s men as goals either side of half-time from Curtis Thompson and Brandon Hanlan saw the Wanderers into the top spot in League One.

Things started brightly for Oxford, and they had the first big chance of the game.   Ryan Williams cut back beautifully to Nathan Holland, but the resulting effort was brilliantly cleared off the line by Ryan Tafazolli and Wycombe kicked on from there.

The breakthrough came on 33 minutes when Simon Eastwood couldn’t claim the ball from a Wycombe set piece.  The ball in was cleared away only as far as Thompson who calmly finished into the far corner from the edge of the box.

United did improve after the break and came back into it with chances for McCleary and Moore before Wycombe put the nail in the coffin on the hour mark.  The home side reacted on the counter after Mark Sykes was denied and Hanlan found himself with all the time in the world to slot the ball under an outcoming Eastwood.

Karl Robinson attempted to force a response by making all three substitutions straight after the second goal, but it wasn’t to be for the U’s who struggled to create any more clear cut chances.  The game ultimately petered out and finished 2-0.

Image: Quisnovus/ CC BY 2.0 via flickr

Back to the future: Putin’s return to classical geopolitics

0

The Russo-Ukrainian border has been conflict-ridden for over a century. An estimated 100,000 Russian troops now lie in wait on the eastern frontier of Ukraine, ready to test the limits of Western lip service. Diplomatic frenzy has ensued; Joe Biden and Vladimir Putin discussed tensions and exchanged warnings over Ukraine on the 30th of December, whilst US National Security Advisors continue to urge dialogue with Russian Foreign Policy aids. This is nothing new; Russian presence on Ukraine’s eastern-most border has become a routine exercise since the annexation of Crimea in 2014. The strategic importance of Ukraine to Putin’s regime cannot be understated. Since the formation of the USSR in 1922, the insatiable Russian bear has always looked westwards for its next meal. The answer to conflict prevention lies in asking why this happens, and how we might prevent it.

Most of the grand theories of classical geopolitics were sequestered at the end of the Cold War. They were overly totalising, generalising, and universal to explain modern phenomena. The new neoliberal world, with all its messy contradictions and complexities, was simply too vast and too unforeseeable to be predicted with grand theories, most argued. But Putin’s Russia has proven itself to be an exception, reviving the age-old, dusty theories of Halford Mackinder’s ‘Heartland’ and Nicholas Spykman’s ‘Rimland’ from the shadows. If the recent actions of Moscow are explicable, that is where the answer lies.

The inspired military mood of Moscow has prompted much debate amongst geopolitical strategists. Should the West adopt a line of appeasement, nodding to Putin’s unwavering request that the US rescind the eventual admittance of Ukraine and Georgia to NATO? For many analysts, this is just another one of Putin’s bluffs to add to the large catalogue of unrealised threats. To others, Moscow is slowly curating a milieu to exploit as a pretext for military invasion. Either could be possible. 

That is why it is essential that the US, amongst other Western powers, take the initiative to mobilise active troops within Ukraine – albeit, without the intent to ever raise a fist. If the US is seen to flinch when clarion calls are issued and violence is threatened to be exerted, the consequences for global geopolitics could be fatal. Wars occur not when aggression is snuffed out early, but when peace is no longer deemed to be worth fighting for.

The best way to prevent war is not to deploy troops once it has already started – it is to ensure that the guns are never loaded in the first place. To achieve this, however, politicians and strategists must learn to identify the precursors of war when they lie brazenly before us, much like a canary in a coal mine. History proves that large-scale conflicts do not erupt out of thin air. They occur when flickers of unchecked aggression become the status quo. And they also occur when pacifists become blind to division and identity politics, which sow the seeds for hatred, blame, and anger. Recognising the rationale for Putin’s foreign policy is good, but understanding the common denominator in the outbreak of war alongside that is even better. 

The most famous translation of geopolitical hypothesis into geopolitical reality has been through Halford Mackinder’s ‘Heartland’ theory. Mackinder postulated that control over the core of Eurasian territory would be the key to global power:

“Who rules Eastern Europe commands the Heartland

Who rules the Heartland commands the World-Island

Who rules the World-Island commands the world”

The ‘Heartland’ would be the most advantageous geopolitical location, located at the pivot of Eurasia, inaccessible by militant sea-vessels, and impregnable through its harsh winters and vast land fortress. He argued that power would lie in the victory of the dominant land powers over the sea powers. This was built upon by Spykman’s ‘Rimland’ theory, which argued that the strip of coastal land surrounding Eurasia was more significant. The ethos of these theories can be seen in the repudiation of the Molotov-Ribbentrop pact, and Hitler’s invasion of the USSR in 1941. Despite sealing the diplomatic promise that Nazi Germany and the Soviet Union would not invade one another during the Second World War, Hitler chose to do so anyway. Rather than being a symptom of power-hungry petulance, it was likely that gaining control of Eastern Europe, or the ‘Heartland’, was always in the Nazi blueprint. After all, the chief Nazi geopolitician, Karl Haushofer, was an avid disciple of Mackinder’s work which explicitly outlined that the successful invasion of Russia by a Western European nation could be used as a catalyst for the reclamation of global hegemony. 

Putin is the most recent leader to follow suit, but with a new flavour. Of course, these theories are grossly outdated. They were written at a time before airpower had come into fruition, and where the power of the digital world would be nothing other than a figment of one’s imagination. Moscow has chosen to rewrite them instead. 

Amongst other enticements, Putin’s desire to irreversibly absorb Eastern Ukraine into his desired territory can be reduced to two main factors relating to these theories: access to warm water ports, aligning with Spykman’s ‘Rimland’, and the expansion and protection of Eastern land power, reflecting Mackinder’s ‘Heartland’. In a globalised world, the ability to trade with ease brings economic leverage, and leverage brings power. For a country with such vast coastal territory, Russia has appallingly bad access to global sea routes and trading, with many ports frozen year-round. The Crimean Port of Sevastopol is a missing piece to Putin’s strategic puzzle, providing warm water access to global shipping routes and allowing the Russian military to aggrandise control into the Black Sea and further beyond. Secondly, as in traditional cold-war fashion, any westwards territorial expansion is deemed as advantageous to the Russian regime, who see the US and NATO as omnipresent and ever-looming threats. To understand the actions of Putin, it is critical we attempt to analyse his motives. These examples do not tell us that Putin will invariably stick to Mackinder and Spykman’s geopolitical blueprints. But, crucially, they demonstrate that diplomacy over the new ‘Eastern Question’ only serves to kick the can down the road. If the well-thumbed geopolitical playbook continues to be followed with increasing resolve, we should preemptively prepare for escalated flare-ups along Ukraine’s eastern border.

Just as much as it is important to recognise Putin’s raison d’état, it is equally important to learn the signs of warmongering before conflict is allowed to ensue. Large scale wars are not momentary spasms in the peacekeeping status quo but rather emerge when small-scale escalations of violence are left unchecked. The First World War was not a global bicker over who was responsible for the assassination of Archduke Franz Ferdinand; it was the culmination of decades of colonial jostling, battles for naval supremacy, and military sabre-rattling. By the same token, the outbreak of The Second World War was steeped in years of uncurbed aggression extending from Nazi Germany, both in its domestic and foreign affairs. Appeasement does not work when you are sat across the table from warmongers. The placement of Russian troops on the Ukrainian border may only seem like a momentary spasm in the otherwise smoothly running peacekeeping operations of Europe. But it is these very glitches which, when left unchallenged, can mutate into actions far more deleterious. 

Biden claiming that stationing US troops in Ukraine was “not on the table” is therefore a serious diplomatic blunder, severely weakening NATO’s standing by ruling out preventative military responses to Russian aggression. Global security cannot be left strictly to the realm of rhetoric. When world leaders claim their unwavering support for the retention of autonomy, sovereignty, and democracy, boundaries must be drawn and the red-line must be enforced. Otherwise, we risk it becoming clear to firebrands that the words of our leaders are just mere paper promises. The US withdrawal from Afghanistan in the summer of 2021 is one of the first obvious signs of an increasingly arthritic western backbone. This will only add teeth to the expansionist desires of Putin, Xi Jinping, and other global autocrats who will surely be looking to relish the opportunity to bring a beleaguered United States to heel. When true colours are shown in flickers of violence, it is imperative that global powers with the capabilities to do so stand strong and unflinching if confronted. Failure to do so only invites the threshold to be increased even further.

Where wars are waged, identity politics are often widespread and deeply ingrained. To prevent conflict, we must first recognise the growing splinters of division within and between our societies. Consider, for instance, how Putin has deftly exploited means of cultural power in order to ensure the rapid Russification of eastern Ukrainian territory. Through a long strategy of cultural impregnation, Crimean’s – pro-Russian or not – now have no choice but to be Russian; their hotels are filled with state bureaucrats, the Russian flag is raised high over many buildings, and the rouble has become the norm. 

This strategy can be easily traced too. Putin has had no qualms in expressing his nostalgia for the USSR and remorse for its collapse. The expansionist outlook peddled by Putin’s politics is strongly reflected in Pan-Slavism and Russian populism which are nostalgic over the restoration of Russian-speaking territories and are reminiscent of the similar mythologies of pan-Germanism and Italian irredentism. Identity politics does not just latch onto unifying principles, but also divisive ones, working in zero-sum terms; one population cannot thrive alongside the survival of another. The absorption of one group forecasts the eradication of a different one. Consider, for instance, Putin’s claim that “Russians and Ukrainians were one people”, and that ethnic Ukrainians do not actually exist. The 6-7% of Western Ukranians who would banish Russians from Ukraine would likely be the group at the brunt end of this policy. Where there is a guise of unifying identity politics, we must learn to recognise the ossifying polarisation occurring beneath the surface. These are, after all, the very ‘unifying’ claims which are preached by war-hungry regimes.

For every war that has been waged, the warning signs and flashes of danger seem obvious in retrospect: expansionism starts with a hypothesis – for Putin, this is the ‘Heartland’ and ‘Rimland’; Ideology and division are then used to wed factionalism and disunity within a society, weakening their resilience. We must learn these signs for the sake of peacekeeping. Putin’s recent threats of encroachment should not be taken lightly by Western powers; economic sanctions and diplomacy have been unable to alchemise Putin’s hunger for Eastern Ukraine. The Russo-Ukrainian tensions should be recognised for what they are: a situation of Chekhov’s gun. The pistol has already appeared in the story, and if NATO powers do not stand resolute and act fast, it is inevitable that shots will be fired. As 2022 marks the centenary of the formation of the Soviet Union, we ought to be wary of a new and junior spectre looking to once again reach its hand into the depths of Eastern Europe.

Artwork by Ben Beechener

Vaccine inequality: Disparity in the distribution of the Oxford-AZ vaccine around the world

0

Omicron has spread across the country, and it looks inevitable that we will soon surpass  200,000 daily cases. More than 1% of the country have tested positive for COVID in the last week, and the danger of novel COVID-19 variants has never been more clear. Each new person infected with COVID comes with increased potential for another mutation of the virus that could make it more infectious, or more able to breakthrough the protection created by vaccines. It is in all of our interest, therefore, to prevent the spread of the virus across the planet. Despite this apparent motivator to protect people worldwide, the United Kingdom, among others, is now giving its citizens their third dose of the vaccine despite almost 40% of the global population remaining unvaccinated. Among low-income counties, less than 10% have had even one dose. 

The blame for this disparity can be put at the feet of many. At the encouragement of the Bill and Melinda Gates Foundation, the vaccine developed at Oxford was licensed exclusively to the multinational AstraZeneca (AZ). This is despite the fact that the vaccine platform used was 97% publicly funded The defence of this move at the time was that the vaccine would be offered ‘at cost’ (not for profit) everywhere for the duration of the pandemic and in perpetuity in low-income counties. However, much of the manufacturing of these vaccines has been done at India’s Serum Institute, which via some clever licencing arrangements has avoided this restriction, charging $7 per dose for the vaccine in Uganda, where the EU was charged $2 per dose by AZ. Given the terms of the agreement, it seems unsurprising that AZ appears to be in no rush to sell vaccines at cost to low-income countries, who remain essentially unvaccinated.

The reasoning behind Oxford University agreeing to this deal could seem unclear, given the proposed alternative of releasing the licence to produce the vaccine for free, “Open Source”. A very cynical answer would be the substantial profits that the University stands to make from the deal. These include $10 million upfront, a further $80 million in “milestone payments”, and 6% of any profits made. I would argue though that a larger cause is a pervasive neoliberal ideology. A sincerely held belief that there is no effective motivator beyond profit. In this framing, it is held that without the potential for a multi-billion dollar company to make money from a tragedy the vaccine would not be produced safely and effectively.

While the exact involvement of the Bill and Melinda Gates Foundation is unclear, I think it is unsurprising that Bill Gates, once CEO of Microsoft, would oppose the principles of Open Source. During his tenure at the company, it used the internal policy of “Embrace, Extend, Extinguish” to systematically disadvantage competitors by crushing Open Source projects. The dynamics of commercial pharmacology are different from those of computing, but I believe they are nonetheless worth comparing. To some, the work done by others, made available for them for free, is little more than a potential for more profit.

It is an open question where we can go from here. One proposal with widespread backing, headed by India and South Africa, was to waive patent protections for COVID vaccines internationally. This would allow countries to produce their own vaccines at cost, and could dramatically accelerate the worldwide rollout of the vaccines, helping us all. The move, opposed by the UK, has its own problems, many of which could be resolved by a more thorough sharing of data by vaccine manufacturers, a truly Open Source approach.

The pandemic is not unique in showing the greed of private corporations, but it does bring into sharp contrast the profound global inequalities that exist in healthcare, exacerbated by the actions of private capital, and founded on a political philosophy that can see no good beyond profit. Global health is one area among many where public goods are co-opted by private interests to turn a profit. It is one area among many where lives could be improved by principles of openness, sharing, and transparency in the goal of the common good.

Image: geralt via Pixabay 

Dirk Bogarde’s Psychosexual Nightmare

0

There are two types of creative genius. There is the kind that can turn their hand to any theme and bring it to beautiful fruition. Think Shakespeare, the Beatles or Beethoven. The second type ploughs a single furrow many ways, telling one story: themselves. Every song Nina Simone sang throbbed with the pain of the African-American struggle, every Haruki Murakami protagonist has the same taste in music, and every Hitchcock protagonist has the same taste in blondes.

But what about actors? Can an actor — a job that by definition demands disguise and versatility in service of someone else’s vision — continue to tell the story of themselves? I can think of at least one actor who did just that for most of his career: Dirk Bogarde.

Dirk Bogarde was one of Britain’s most beloved leading men in the 1950s, nicknamed ‘Idol of the Odeons’ for his slew of performances in matinee pulp produced by the Rank Organisation. In the 1960s he turned his back on romantic fluff in favour of a series of darker and more complex roles. He ultimately rejected the British film industry altogether to work with European art film-makers like Luchino Visconti, including his best known role in Death in Venice. The latter part of his life was largely spent in a peaceful farmhouse in Provence, living with his partner, Anthony Forwood, and writing an impressive quantity of memoirs and novels. His autobiographies are witty collections of anecdotes and reflections on his early adulthood, his acting life, his experience of France and much more. Not a single one alludes to the fact that he was gay.

Dirk Bogarde did not come out during his lifetime. In 1986, not long before inviting TV chat show host Russell Harty to his home for an in-depth profile, he destroyed a host of letters and diaries in a bonfire in his back garden. With this act, and silence on the matter after Forwood’s death in 1988 until his own in 1999, the details and exact nature of their relationship died with both parties,. But for almost anyone who knows one thing about him beyond his name and occupation, Bogarde’s sexuality has never been in doubt. This is largely down to anecdotal evidence provided by many of his contemporaries and close friends, made public after his death in the documentary The Private Dirk Bogarde, and John Coldstream’s biography. However, these posthumous affirmations alone do not account for how vividly Bogarde’s perception as a gay man has persisted in public consciousness. I would maintain that despite his reticence on the subject in interviews, Dirk Bogarde was always telling the story of himself. Partly in his books — as he archly commented to Harty in that same profile, “you’ve got to read between the lines” — and, most remarkably, in his performances.

You do not need to look far for overt examples of this. After his breakaway from Rank, he took the highly controversial lead role in Basil Dearden’s 1961 film, Victim, famously the first English language film to say the word ‘homosexual’ on screen, and also the first with a gay male hero. Radically sympathetic in its portrayal of the torment of gay men being exploited by blackmailers while their very existence was criminalised, the film was a monumental risk that Bogarde took with passion and enthusiasm. He even penned a crucial scene himself, where his character Melville admits the truth to his wife, that he desired the young man who was blackmailed into suicide. “You won’t be content until you’ve ripped it out of me,” he says. “I stopped seeing him because I wanted him.” Bogarde would consistently single out Victim as his proudest screen achievement, not least due to its role in changing anti-gay legislation by swaying public opinion enough to pass the Sexual Offences Act in 1967.

Melville was the most overt and positively depicted role in a long line of queer and queer-coded characters in Bogarde’s repertoire. There was the terminally ill Aschenbach in Death in Venice, silently tortured by his longing for a beautiful youth, the subtly camp and unrepentantly wicked protagonist of Cast A Dark Shadow, the far less subtly camp and outrageous villains of Modesty Blaise and The Singer Not The Song, and the sinister Barrett of Joseph Losey’s The Servant. It bears comment that very few if any of these roles could be called positive, or even valid queer representation – nearly always villainous characters, quite often unceremoniously killed by the end of the film’s runtimes, these were the Hays Code-compliant depictions of homosexuality that audiences were quite well-accustomed to. What is remarkable is seeing Bogarde’s face on so many of them after he had established himself as Rank’s go-to man for a handsome heterosexual lead for most of the ‘50s. Yet even in these earlier performances, you’d find the textbook cinematic codes that would fly over an unheeding viewer’s head:  a fraught and loveless marriage here, an offhand reference to interior décor there, his trademark saucy eyebrow quirk persisting through it all.

But when I talk of Bogarde ‘telling the story of himself’ through his performances, I’m not just talking about a few quirked eyebrows and suggestive comments. What shines through in so many of his films is compelling bitterness. Within the Wildean wit and affable flamboyance was a cold, grudge-bearing streak: he had a number of fellow actors and directors  whom he inexplicably viciously turned against, including John Mills and Richard Attenborough. On film work, he stated flippantly but firmly in a letter to film critic Dilys Powell, “I detest the job and most of the time I detest the people.”

This dichotomous personality may have been forged in the threefold fire of unresolved trauma from WWII, the stress of keeping his sexuality a secret in the public eye, and the buttoned-up gentlemanly affect he perfected. “I didn’t make it this far by being cuddly and dear,” he said in response to Russell Harty commenting on his prickliness. Flashing one of his charming, withering smiles, he added, “People need to be taught a lesson sometimes.” It is these glimpses of venom, the satisfied smirk from behind a well-curated mask of pleasant English normalcy that I find alluring about Bogarde, and it’s that that I look for in his performances. 

This quality was picked up while he was still performing under Rank. While his reputation as a smiling leading man throughout the fifties has prevailed, a quick look at his filmography from the time reveals that he was also often taken on for villainous or otherwise dark roles, such as the murderers on the run in Hunted and The Blue Lamp. Even his heroic characters are sometimes betrayed by a certain artificiality and aloofness in their eyes, something that film production duo Powell and Pressburger noticed with displeasure about his performance as the daring Major Patrick Lee Fermor in Ill Met by Moonlight.

In the ’60s he began to embrace that inner darkness, opening the shutters to allow a look into that well of rage. We see it in the righteous anger of Victim, but arguably in more fascinating detail in The Servant. While it is his most sincere and moving performance, Melville is an anomaly in Bogarde’s work: an honest-to-god hero acknowledged to be gay. Barrett, meanwhile, is a character plucked from the abyss, the trickster in a fable made nightmarish. The titular servant enters the home of a layabout young aristocrat, Tony. He asserts his power and ultimately manipulates Tony into a pit of debauchery and degradation for his own pleasure.

The film is a heady, psychosexual feast that hinges on Bogarde’s mesmerising performance. In the film’s early sections, he is reserved, a little effete, quietly deferent to his master’s wishes but particular about his own tastes, especially where decorating the house is concerned. His malice first reveals itself in small shows of passive aggression, and then in sudden shifts into gleeful sexual rapaciousness once he and the maid are alone together. His demure, restrained energy is fully unleashed in the second half of the film, which sees professional boundaries dissolved as he and Tony tear at each other. The two devolve into childlike states, playing schoolyard games, petulantly lashing out one minute and falling into each other’s arms the next. Once Tony has been reduced to a drugged up, placid doll, Barrett looks at him with unmasked pleasure, affection and sadism mingling sickeningly on his face. He is an agent of havoc whose intentions are never fully revealed, and in lesser hands could be nothing more than a fixture of horror, but in Bogarde’s, we see a soul twisted by a life of repression and resentment.

Ultimately, that is the singular story of Bogarde’s career: the vengeful anguish of repression. The Servant makes that anguish its curdled centre, resulting in a desire that only knows how to destroy. In Barrett, Bogarde luxuriated in a side of himself that he could allow to be cruel, lascivious and ungentlemanly. And even more satisfyingly, he could direct that malice towards the walking metaphor for English polite society, pushing it to the ground to lie at his feet. Throughout his career, that dark desirous side would imbue his screen presence with an arresting intensity that always said: this is my story.

Image Credit: Film Star Vintage/CC BY 2.0